
Highlights
WHAT IS IT?
A spot treatment cream with multiple ingredients
FEATURES
CentellAC-Rx Complex, Overnight treatment, Dual Block System container
BEST FOR
Acne-prone, sensitive skin
CHECKS
Free of sulfates, parabens
Who Is It For?
Adults Both Women And MenWhat Does It Help With?
Acne Blemishes Redness IrritationBudget
Mid-rangeHow To Use
Which routine should it be used in?
Instructions:
Key Information
What COSRX Says
Product Description:
A spot treatment which adheres to growing acne to effectively and quickly overcome areas of concern. It contains CentellAC-Rx Complex that helps revitalize and recover the skin without irritation. The formula gently dries out visible acne overnight using a skin-recovery complex with Zinc Oxide, Calamine, CentellAC-RX Complex and Aloe Barbadensis Leaf Water.
About the Brand:
Ingredients Overview
Ingredients List
Aloe Barbadensis Leaf Water, Butylene Glycol, Helianthus Annuus (Sunflower) Seed Oil, Glycerine, Zinc Oxide, Cetearyl Alcohol, Dimethyl Sulfone, Betaine, Polysorbate 60, Elaeis Guineensis (Palm) Oil, Elaeis Guineensis (Palm) Kernel Oil, Cetearyl Olivate, Sorbitan Olivate, 1,2-Hexanediol, Calamine, Dimethicone, Illicium Verum (Anise) Fruit Extract, Scutellaria Baicalensis Root Extract, Xanthan gum, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Ethyl Hexanediol, Asiaticoside, Asiatic acid, Madecassic acid
Key Ingredients
CentellAC-Rx Complex (Madecassic acid, Asiaticoside, Asiatic acid), Zinc Oxide, Calamine, Aloe Barbadensis Leaf Water, Tea Tree Leaf Oil
Ingredients Details
Betaine
Common Name(s): Trimethylglycine,tmg,natural betaine
CAS Number: 107-43-7
DESCRIPTION
What It Does: Provides osmoprotective humectant conditioning with anti-irritant and mild foam-boosting activity.
Why It's Used: Natural-origin multifunctional osmolyte from sugar beet providing hydration, anti-irritancy, and conditioning in virtually every cosmetic category.
How It Works: Quaternary ammonium betaine provides zwitterionic character for water binding via ionic hydration. osmoprotective function at 100โ500mm as compatible solute protecting cells from osmotic stress. reduces surfactant irritation by competing with sls for protein binding sites. mild foam enhancement.
Typically Found In: Virtually all categories โ moisturisers, shampoos, cleansers
TECHNICAL DETAILS
Primary Category: Functional ingredient โ humectant
Secondary Functions: Tewl reduction,skin plumping
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ10%
SOURCING & ETHICS
Vegan Status: Yes โ from beta vulgaris (sugar beet) molasses
Halal Status: Yes
Source Notes: Synthetic or naturally derived. excellent aqueous solubility.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Betaine's anti-irritant mechanism for surfactant systems involves competitive protein protection: betaine at high concentrations preferentially interacts with skin proteins, occupying binding sites that would otherwise be occupied by surfactant molecules causing protein denaturation. this competition reduces available protein binding for irritating surfactants, explaining betaine's well-documented ability to reduce sls irritation when co-formulated.
Last Verified: Cosing database,craig betaine osmoprotective review,cir safety assessment
Primary Sources: 2026-03-12
Butylene Glycol
Common Name(s): 1,3-butanediol,bg,1,3-butylene glycol
CAS Number: 107-88-0
DESCRIPTION
What It Does: Provides humectant hydration and active ingredient solubilization with excellent skin feel.
Why It's Used: Preferred glycol humectant in premium and k-beauty formulations for superior skin feel vs propylene glycol with equivalent functionality.
How It Works: Two hydroxyl groups at 1,3-positions provide water binding and solvent activity. better tolerated than propylene glycol with minimal sensitization risk. 4-carbon backbone provides slightly greater hydrophobic character enabling dissolution of less polar actives vs pg.
Typically Found In: Toners,essences,serums,k-beauty formulas
TECHNICAL DETAILS
Primary Category: Functional ingredient โ glycol humectant
Secondary Functions: Tewl reduction,skin plumping
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1%โ10%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic
Halal Status: Yes
Source Notes: Synthetic or naturally derived. excellent aqueous solubility.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
K-beauty's preference for butylene glycol over propylene glycol is driven by two factors: bg's superior skin feel (less tacky than pg's higher viscosity) and its lower sensitization potential (1,3-bg has better spatial distribution of hydroxyl groups that reduces protein interaction vs pg's 1,2-position oh groups).
Last Verified: Cosing database,cir safety assessment
Primary Sources: 2026-03-12
Cetearyl Alcohol
Common Name(s): Cetostearyl alcohol,c16-18 fatty alcohol
CAS Number: 8005-44-5
DESCRIPTION
What It Does: Provides fatty alcohol emulsification and thickening for stable, well-textured emulsions.
Why It's Used: The most widely used fatty alcohol in cosmetics โ provides emulsification, thickening, and emolliency simultaneously from a single ingredient with excellent safety profile.
How It Works: Forms bilayer lamellar structures in water with emulsifiers creating a viscous structured network that thickens and stabilizes emulsions. fatty alcohol emolliency provides direct skin conditioning. bilayer formation reduces inter-droplet coalescence in emulsions.
Typically Found In: Creams,lotions,conditioners โ virtually all emulsion products
TECHNICAL DETAILS
Primary Category: Functional ingredient โ fatty alcohol emulsifier/thickener
Secondary Functions: Barrier sealing,softening
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1%โ25%
SOURCING & ETHICS
Vegan Status: Yes โ from vegetable or coconut/palm fatty acids
Halal Status: Yes
Source Notes: Plant-derived, synthetic or animal-derived. verify source.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 1/5 โ low; formulation-dependent
Sensitivity Concerns: Non-irritating.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Humectants,ceramides,actives as carrier
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Cetearyl alcohol's ability to form lamellar liquid crystal structures ('krafft phases') with water and co-emulsifiers provides not only emulsion stability but also enhanced skin penetration via the lamellar skin barrier pathway. these crystalline structures can act as a reservoir for active ingredients, slowly releasing them as the lamellar structure melts on skin contact.
Last Verified: Cosing database,cir safety assessment
Primary Sources: 2026-03-12
Dimethyl Sulfone
Common Name(s): Msm,organic sulfur,anti-inflammatory sulfur
CAS Number: 67-71-0
DESCRIPTION
What It Does: Provides anti-inflammatory organic sulfur for skin strengthening from msm.
Why It's Used: Bioavailable organic sulfur anti-inflammatory โ msm provides the sulfur required for keratin disulfide bonding and collagen sulfur amino acids alongside anti-inflammatory activity, making it a functional sulfur supplement for both structural skin proteins and inflammatory skin conditions.
How It Works: (ch3)2so2: highly bioavailable sulfur. anti-inflammatory: nf-kb inhibition + oxidative stress reduction. keratin: disulfide bond sulfur source. collagen: methionine + cysteine content. anti-acne: anti-inflammatory + antimicrobial. oral supplement: joint pain, anti-inflammatory. topical: skin brightening + anti-inflammatory.
Typically Found In: Anti-inflammatory skin care,strengthening products
TECHNICAL DETAILS
Primary Category: Active ingredient โ cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1%โ10%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Msm sulfur bioavailability: msm's dimethyl sulfone form provides sulfur without the digestive hydrogen sulfide issues of inorganic sulfates. topically, msm penetrates sc readily from low mw (94 da) + high oil-water partition compatibility, delivering sulfur to dermis for keratin/collagen synthesis cofactor function. this combination of sc penetration + sulfur bioavailability makes msm the most practical topical sulfur supplement.
Last Verified: Cosing database,msm anti-inflammatory review
Primary Sources: 2026-03-12