Alpine Arnica & Magnesium Gel

DESCRIPTION

What It Does: Provides the gentlest chemical exfoliation with simultaneous antioxidant, moisture retention, and barrier support.

Why It's Used: Preferred exfoliant for rosacea, eczema, sensitive skin, and post-procedure recovery where standard ahas cause unacceptable irritation.

How It Works: Hydrolyzes slowly on skin surface to gluconic acid providing gentle exfoliation. multiple hydroxyl groups enable water binding (humectant) and metal chelation (antioxidant).

Typically Found In: Sensitive skin exfoliants,rosacea treatments,eczema care,post-procedure recovery

TECHNICAL DETAILS

Primary Category: Active ingredient – polyhydroxy acid (pha)

Secondary Functions: Gentle exfoliation,antioxidant,humectant

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 5%–15%

SOURCING & ETHICS

Vegan Status: Yes – fermentation or synthetic

Halal Status: Yes

Source Notes: Fermentation-derived from glucose or synthetic. among the safest chemical exfoliants available.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: No photosensitization; no stinging; suitable for very sensitive skin.

Safe for Sensitive Skin: Yes – ideal for sensitive, reactive, rosacea, and eczema-prone skin; no photosensitization

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. no photosensitization. ewg score: 1.

Works Well With: Ceramides,niacinamide,hyaluronic acid,soothing actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Phas have molecular weights 2–3× larger than ahas, limiting penetration to superficial layers. combined humectant and antioxidant properties make them uniquely well-tolerated while providing meaningful exfoliation.

Last Verified: Cosing database,green & yu (2003) pha review,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Activates trpm8 cold thermoreceptors for intense cooling sensation and analgesic activity.

Why It's Used: The most potent cosmetic cooling agent – direct trpm8 agonist providing cooling sensation without actual temperature reduction for refreshing and analgesic formulations.

How It Works: Potent trpm8 (menthol receptor/cold thermosensor) agonist – activation at room temperature mimics cold sensation without actual cooling. anti-pruritic via trpm8 activation competing with itch c-fiber signaling. antimicrobial via membrane disruption.

Typically Found In: Cooling products,scalp treatments,oral care,pain relief,foot care,after-sun

TECHNICAL DETAILS

Primary Category: Active ingredient – cooling sensory terpenoid

Secondary Functions: Redness reduction,anti-inflammatory,calming

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – from mentha piperita or synthetic

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate; potential sensitizer

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Avoid near eyes. use with caution at concentrations above 1% for sensitive skin.

SAFETY & COMPATIBILITY

Safety Profile: Eu max 4.5% (leave-on); regulations vary by application site. avoid on infants' face.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Menthol's exceptional cooling potency stems from its ec50 for trpm8 activation of approximately 10μm (vs camphor's ec50 of ~5mm – 500× lower potency). this 500× potency advantage explains why even tiny concentrations of menthol provide intense cooling, while much higher concentrations of camphor are required for equivalent sensation.

Last Verified: Cosing database,mckemy et al. menthol trpm8 discovery,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Helps oil and water blend in creams and lotions while conditioning skin.

Why It's Used: Polyglyceryl-4 head provides hydrophilicity (hlb ~7–9); capric acid (c10) tail provides oil-phase affinity; natural-origin compatible.

How It Works: Polyglycerol-4 backbone with capric acid (c10) ester tail; hlb ~7–9; polyglyceryl esters are widely used natural-origin emulsifiers suitable for organic cosmetic certification.

Typically Found In: O/w emulsions,natural cosmetics,organic formulations,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – emulsifier

Secondary Functions: Skin conditioning,surfactant,natural origin

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Polyglycerin from vegetable glycerol polymerization; capric acid (c10) acid from plant sources; naturally derived.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low

Sensitivity Concerns: Very mild; suitable for sensitive skin. natural-origin ingredient.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Natural oils,plant butters,other natural emulsifiers,humectants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pg-4 caprate; c10 capric chain; balanced emulsification hlb ~7-9; non-greasy.

Last Verified: Cosing database,inci dictionary,supplier technical data

Primary Sources: 2026-03-27

DESCRIPTION

What It Does: Helps oil and water blend in creams and lotions while conditioning skin.

Why It's Used: Polyglyceryl-6 head provides hydrophilicity (hlb ~9–11); caprylic acid (c8) tail provides oil-phase affinity; natural-origin compatible.

How It Works: Polyglycerol-6 backbone with caprylic acid (c8) ester tail; hlb ~9–11; polyglyceryl esters are widely used natural-origin emulsifiers suitable for organic cosmetic certification.

Typically Found In: O/w emulsions,natural cosmetics,organic formulations,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – emulsifier

Secondary Functions: Skin conditioning,surfactant,natural origin

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Polyglycerin from vegetable glycerol polymerization; caprylic acid (c8) acid from plant sources; naturally derived.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low

Sensitivity Concerns: Very mild; suitable for sensitive skin. natural-origin ingredient.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Natural oils,plant butters,other natural emulsifiers,humectants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pg-6 caprylate; very short chain c8; very high hydrophilicity from pg-6; o/w emulsification hlb ~9-11; mild antimicrobial.

Last Verified: Cosing database,inci dictionary,supplier technical data

Primary Sources: 2026-03-27

DESCRIPTION

What It Does: Delivers copper in a highly bioavailable organic-complexed form for cofactor supplementation of copper-dependent skin enzymes, supporting barrier formation, antioxidant defence, and collagen cross-linking.

Why It's Used: Yeast-fermented copper provides organic mineral complexes (amino acid chelates, nucleotide complexes) with documented higher skin uptake than equivalent inorganic copper salts — the protein matrix providing bioaccessibility advantages.

How It Works: Saccharomyces cerevisiae accumulates copper ions intracellularly during fermentation, forming stable organic complexes with yeast proteins, glutathione, and nucleic acids. these organic copper complexes have higher logp and membrane permeability than inorganic ions — providing better transepidermal delivery and utilisation by skin enzymes.

Typically Found In: Mineral skin care,enzyme support

TECHNICAL DETAILS

Primary Category: Active ingredient – skin microbiome support

Secondary Functions: Microbiome balance,prebiotic effect

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Fermentation-derived or plant-extracted.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; beneficial for sensitive skin.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,niacinamide,soothing actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Yeast-fermented copper follows the same bioavailability principle as selenium yeast in nutrition — organically complexed selenium in yeast is 2–3× more bioavailable than selenite. the organic matrix prevents the ionic precipitation reactions that limit inorganic mineral bioavailability in biological environments.

Last Verified: Cosing database,saccharomyces copper ferment bioavailable mineral review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers iron in a highly bioavailable organic-complexed form for cofactor supplementation of iron-dependent skin enzymes, supporting barrier formation, antioxidant defence, and collagen cross-linking.

Why It's Used: Yeast-fermented iron provides organic mineral complexes (amino acid chelates, nucleotide complexes) with documented higher skin uptake than equivalent inorganic iron salts — the protein matrix providing bioaccessibility advantages.

How It Works: Saccharomyces cerevisiae accumulates iron ions intracellularly during fermentation, forming stable organic complexes with yeast proteins, glutathione, and nucleic acids. these organic iron complexes have higher logp and membrane permeability than inorganic ions — providing better transepidermal delivery and utilisation by skin enzymes.

Typically Found In: Mineral skin care,enzyme support

TECHNICAL DETAILS

Primary Category: Active ingredient – skin microbiome support

Secondary Functions: Microbiome balance,prebiotic effect

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Fermentation-derived or plant-extracted.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; beneficial for sensitive skin.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,niacinamide,soothing actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Yeast-fermented iron follows the same bioavailability principle as selenium yeast in nutrition — organically complexed selenium in yeast is 2–3× more bioavailable than selenite. the organic matrix prevents the ionic precipitation reactions that limit inorganic mineral bioavailability in biological environments.

Last Verified: Cosing database,saccharomyces iron ferment bioavailable mineral review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers zinc in a highly bioavailable organic-complexed form for cofactor supplementation of zinc-dependent skin enzymes, supporting barrier formation, antioxidant defence, and collagen cross-linking.

Why It's Used: Yeast-fermented zinc provides organic mineral complexes (amino acid chelates, nucleotide complexes) with documented higher skin uptake than equivalent inorganic zinc salts — the protein matrix providing bioaccessibility advantages.

How It Works: Saccharomyces cerevisiae accumulates zinc ions intracellularly during fermentation, forming stable organic complexes with yeast proteins, glutathione, and nucleic acids. these organic zinc complexes have higher logp and membrane permeability than inorganic ions — providing better transepidermal delivery and utilisation by skin enzymes.

Typically Found In: Mineral skin care,enzyme support

TECHNICAL DETAILS

Primary Category: Active ingredient – skin microbiome support

Secondary Functions: Microbiome balance,prebiotic effect

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Fermentation-derived or plant-extracted.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; beneficial for sensitive skin.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,niacinamide,soothing actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Yeast-fermented zinc follows the same bioavailability principle as selenium yeast in nutrition — organically complexed selenium in yeast is 2–3× more bioavailable than selenite. the organic matrix prevents the ionic precipitation reactions that limit inorganic mineral bioavailability in biological environments.

Last Verified: Cosing database,saccharomyces zinc ferment bioavailable mineral review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antioxidant protection from reactive oxygen species, reduces inflammatory cytokine production in skin, and conditions skin through the plant's phytochemical complex.

Why It's Used: Natural origin narrative, traditional use heritage, and multi-functional phytochemical profile supporting concurrent skin care claims from one ingredient.

How It Works: Polyphenols, terpenoids, and alkaloids scavenge ros via h• donation, inhibit nf-kb or cox-2 inflammatory pathways, and interact with skin surface proteins for conditioning.

Typically Found In: Botanical skin care,natural products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Plant secondary metabolites evolved as photoprotectants and antimicrobials — mechanisms directly applicable to cosmetic antioxidant and anti-inflammatory activity in human skin.

Last Verified: Cosing database,salix nigra (willow) bark extract botanical review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides natural thickening while delivering beta-glucan immunomodulatory and wound healing activity.

Why It's Used: Natural thickener with functional benefit (beta-glucan immunostimulation) beyond simple rheology – combines formulation function with skin bioactivity.

How It Works: Triple-helix beta-1,3-glucan backbone with 1,6 branches provides strong entanglement-based thickening. beta-glucan activity activates dectin-1 receptors on immune cells for wound healing stimulation. excellent salt and ph stability.

Typically Found In: Natural cosmetics,wound healing products,natural gels

TECHNICAL DETAILS

Primary Category: Functional ingredient – natural microbial polysaccharide

Secondary Functions: Beta-glucan immunostimulation,wound healing

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.2%–2%

SOURCING & ETHICS

Vegan Status: Yes – sclerotinia rolfsii fermentation

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Sclerotium gum's triple-helix conformation in solution provides unusual for polysaccharides: a gel-like structured phase at very low concentrations due to helix-helix aggregation. this allows effective thickening at 0.1-0.3% concentrations, compared to xanthan's 0.3-0.5% minimum effective concentration.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides comprehensive yeast-derived antioxidants, vitamins, and beta-glucan for multi-active skin conditioning.

Why It's Used: Economical multi-active yeast extract combining coq10, glutathione, beta-glucan, and b vitamins in a single fermentation-derived ingredient.

How It Works: Beta-glucan from cell wall activates dectin-1 for wound healing. ergosterol (provitamin d2) provides structural membrane support. endogenous glutathione provides intracellular antioxidant support. coq10 provides mitochondrial antioxidant activity.

Typically Found In: Natural anti-aging products,yeast skincare,b vitamin formulas

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Multi-active yeast complex,natural coq10+glutathione

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–10%

SOURCING & ETHICS

Vegan Status: Yes – from saccharomyces cerevisiae

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Saccharomyces cerevisiae's status as the most intensively studied eukaryotic organism means its cellular biochemistry – including the specific antioxidant and barrier-supportive molecules it produces – is better characterized than any other organism used in cosmetic fermentation. this scientific knowledge base provides exceptional understanding of the biological rationale for yeast extract skin benefits.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12