AXIS-Y Biome Ultimate Indulging Cream

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

1-2-hexanediol has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,1-2-hexanediol technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Reduces fine lines, stimulates collagen, firms skin, and reduces inflammation.

Why It's Used: Fda-recognized anti-wrinkle active with multi-action collagen stimulation + wrinkle reduction + anti-inflammatory efficacy.

How It Works: Activates adenosine a2a receptors on fibroblasts stimulating collagen type i. also activates pka pathway promoting atp production and reducing inflammatory cytokines.

Typically Found In: Anti-aging serums,wrinkle treatments,korean skincare

TECHNICAL DETAILS

Primary Category: Active ingredient – purine nucleoside / anti-aging

Secondary Functions: Collagen stimulation,anti-inflammatory,cell energy

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.04%–0.1%

SOURCING & ETHICS

Vegan Status: Yes – synthetically produced

Halal Status: Yes

Source Notes: Synthetically produced for cosmetic use.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; excellent tolerability.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. fda-recognized as safe and effective anti-wrinkle ingredient. ewg score: 1.

Works Well With: Other b vitamins,niacinamide,antioxidant complexes

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

A 2002 clinical study demonstrated 0.04% adenosine cream significantly reduced wrinkle depth and increased skin elasticity after 4 weeks. fda recognition requires controlled clinical trial evidence.

Last Verified: Cosing database,adenosine anti-aging clinical data,fda otc anti-wrinkle monograph

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Soothes irritation, accelerates wound healing, promotes skin cell renewal, and provides mild keratolytic exfoliation.

Why It's Used: Gold standard multi-function soothing active – one of the most widely used cosmetic ingredients across all product types for its exceptional tolerability and clinically proven multi-action skin conditioning.

How It Works: Promotes keratinocyte proliferation and fibroblast migration for wound healing. mild keratolytic activity by disrupting corneocyte binding. anti-irritant via direct protein binding and anti-inflammatory cytokine reduction. humectant activity via hydroxyl groups.

Typically Found In: Post-procedure products,sensitive skin formulas,wound care,anti-acne treatments,baby products

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Wound healing,keratolytic,anti-irritant

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – synthetic or comfrey-derived

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Exceptionally well-tolerated; suitable for all skin types including baby and compromised skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Allantoin's keratinocyte proliferation stimulation occurs via receptor-mediated signaling (possibly machr activation) rather than non-specific irritation-driven proliferation, making it a true wound-healing stimulant rather than a pro-inflammatory proliferative signal.

Last Verified: Cosing database,cir safety assessment,araújo et al. allantoin review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Reduces inflammation, deeply hydrates, stimulates collagen synthesis, accelerates wound healing.

Why It's Used: Used in anti-aging, sensitive skin, post-procedure, and eczema care for multi-action anti-inflammatory, moisturizing, and regenerative benefits.

How It Works: Binds to dectin-1 and cr3 receptors on macrophages and keratinocytes activating tgf-beta and collagen synthesis pathways. also activates macrophage phagocytosis for wound healing. humectant from polysaccharide hydroxyl groups.

Typically Found In: Anti-aging serums,sensitive skin products,post-procedure care,eczema treatments

TECHNICAL DETAILS

Primary Category: Active ingredient – polysaccharide / immunomodulator

Secondary Functions: Immunomodulator,wound healing,collagen stimulation

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes – yeast or oat-derived

Halal Status: Yes

Source Notes: Derived from saccharomyces cerevisiae yeast (1,3/1,6-linked) or avena sativa oats (1,3/1,4-linked). molecular weight affects penetration – lower mw for skin penetration vs high mw for surface hydration.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Yeast beta-1,3/1,6-glucan receptor binding to dectin-1 on keratinocytes activates tgf-beta1, the key pro-collagen cytokine, stimulating fibroblast collagen production. this makes beta-glucan one of the few non-retinoid, non-peptide ingredients with direct receptor-mediated collagen stimulation.

Last Verified: Cosing database,wasser (2002) beta-glucan review,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides osmoprotective humectant conditioning with anti-irritant and mild foam-boosting activity.

Why It's Used: Natural-origin multifunctional osmolyte from sugar beet providing hydration, anti-irritancy, and conditioning in virtually every cosmetic category.

How It Works: Quaternary ammonium betaine provides zwitterionic character for water binding via ionic hydration. osmoprotective function at 100–500mm as compatible solute protecting cells from osmotic stress. reduces surfactant irritation by competing with sls for protein binding sites. mild foam enhancement.

Typically Found In: Virtually all categories — moisturisers, shampoos, cleansers

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–10%

SOURCING & ETHICS

Vegan Status: Yes – from beta vulgaris (sugar beet) molasses

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Betaine's anti-irritant mechanism for surfactant systems involves competitive protein protection: betaine at high concentrations preferentially interacts with skin proteins, occupying binding sites that would otherwise be occupied by surfactant molecules causing protein denaturation. this competition reduces available protein binding for irritating surfactants, explaining betaine's well-documented ability to reduce sls irritation when co-formulated.

Last Verified: Cosing database,craig betaine osmoprotective review,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides essential barrier sterol function as one of three critical stratum corneum lipid components.

Why It's Used: Essential component of complete barrier repair formulations – the stratum corneum barrier requires ceramides:cholesterol:fatty acids in approximately 1:1:1 molar ratio for complete barrier restoration.

How It Works: Integrates between ceramide headgroups in lamellar body structures, providing fluidity and flexibility to the otherwise rigid ceramide-dominated lipid matrix. controls lamellar body phase behavior for functional barrier.

Typically Found In: Barrier repair moisturizers,eczema treatments,dry skin formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – barrier sterol

Secondary Functions: Lamellar body structure,barrier sterol

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Conditional – animal-derived (lanolin) or plant-derived phytosterol analogs; verify

Halal Status: Conditional – verify source

Source Notes: Traditionally from lanolin (wool grease). plant-derived cholesterol alternatives include phytosterols, though these show slightly different barrier integration. verify for vegan/halal.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Endogenous molecule; excellent tolerability.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. natural skin component. ewg score: 1.

Works Well With: Other ceramides,cholesterol,free fatty acids,hyaluronic acid,niacinamide

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Elias demonstrated that barrier repair requires all three lipid classes (ceramides, cholesterol, fatty acids) in approximately equimolar ratios. formulations providing only ceramides without cholesterol and fatty acids show significantly inferior barrier restoration vs complete triple-lipid combinations.

Last Verified: Cosing database,elias et al. barrier lipid ratio study,loden barrier repair review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides volatile silicone delivery with longer contact time than d5 for extended active delivery.

Why It's Used: Longer-evaporation volatile silicone for formulations requiring extended delivery contact time vs d5's rapid evaporation.

How It Works: Larger ring (6 silicone units) provides lower vapor pressure than d5 (5 units). slower evaporation rate (2-3× longer than d5) provides extended delivery window. same dry-touch after complete evaporation.

Typically Found In: Longer-duration volatile vehicles,serum formulations

TECHNICAL DETAILS

Primary Category: Functional ingredient – volatile cyclic silicone

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu restrictions on d5 do not apply to d6 – d6 may be used in rinse-off products without restriction.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

The different evaporation rates of d4 (methylcyclosiloxane), d5, and d6 provide formulators with a toolkit of volatile silicone delivery windows: d4 evaporates in ~1 minute, d5 in ~5 minutes, d6 in ~15 minutes. blending these provides precisely tunable evaporation kinetics for specific delivery timing requirements.

Last Verified: Cosing database,dow silicone technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Dextrin has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,dextrin technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antimicrobial skin conditioning with deodorant activity and preservation system enhancement.

Why It's Used: Multifunctional clean beauty preservation active — ethylhexylglycerin provides antimicrobial, deodorant, and skin conditioning in a single ingredient accepted in most natural cosmetic certification schemes.

How It Works: Glycerol ether provides antimicrobial via bacterial membrane phospholipid disruption. deodorant activity via reduction of underarm lipase enzyme activity (similar mechanism to triethyl citrate). skin conditioning from glycerol humectant component. synergistic with phenoxyethanol and diols.

Typically Found In: Natural preservation systems,deodorants,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – antimicrobial glycerol ether

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–0.5%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Ethylhexylglycerin's deodorant mechanism is pharmacologically identical to triethyl citrate: both inhibit skin surface microbial lipase enzymes that convert odourless triglycerides to odorous free fatty acids. the glycerol ether structure of ethylhexylglycerin, combined with the 2-ethylhexyl chain, provides lipase inhibition similar to ester-based lipase inhibitors from a different chemical class.

Last Verified: Cosing database,schülke sensiva sc 10 technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides rapid-acting prebiotic microbiome support with humectant conditioning from short-chain fructan oligomers.

Why It's Used: Fast-acting prebiotic for rapid microbiome support — fos's shorter chain length provides faster fermentation by beneficial bacteria vs long-chain inulin, enabling quicker microbiome compositional shifts.

How It Works: Dp 2-10 fructooligomers (vs inulin's dp 10-60) provide more rapid access to bacterial fermentation enzymes. higher water solubility and humectant activity than long-chain inulin. more bioavailable to skin surface bacteria vs longer-chain inulin that penetrates deeper before fermentation.

Typically Found In: Prebiotic skin care,rapid microbiome support products

TECHNICAL DETAILS

Primary Category: Active ingredient – short-chain prebiotic

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes – from sucrose enzymatic synthesis or inulin hydrolysis

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Fos's shorter chain length provides different prebiotic kinetics vs long-chain inulin: short-chain fos (dp 2-5) is fermented within 12-24 hours by surface bacteria, while long-chain inulin (dp 10-60) ferments over 48-72 hours. this temporal difference enables formulation of 'fast-acting' (fos) vs 'sustained-release' (inulin) prebiotic products with different microbiome support kinetics.

Last Verified: Cosing database,roberfroid fos prebiotic review

Primary Sources: 2026-03-12