PREQUEL
BARRIER THERAPY
BARRIER THERAPY
PREQUEL
barrier-therapy
Moisturize
9873693704485
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Highlights
WHAT IS IT?
Skin protectant cream with colloidal oatmeal and ceramides
FEATURES
Alleviates irritation and itchiness, absorbs easily, provides relief to dry and distressed skin
BEST FOR
dry
CHECKS
Who Is It For?
All AgesWhat Does It Help With?
Dryness Eczema Flare-ups Skin Irritation ItchinessBudget
Affordable (under $30)How To Use
Which routine should it be used in?
Instructions:
Key Information
What PREQUEL Says
Product Description:
A skin protectant cream for the face and body that alleviates minor irritation and itchiness due to dryness and eczema flare-ups. Formulated with a potent blend of colloidal oatmeal, multi-ceramide blend, allantoin and adenosine, this soothing cream absorbs easily and provides relief to dry, distressed skin.
About the Brand:
Ingredients Overview
Ingredients List
colloidal-oatmeal,ceramides,allantoin,adenosine
Key Ingredients
colloidal oatmeal, multi-ceramide blend, allantoin, adenosine
Ingredients Details
Adenosine
Common Name(s): Adenine riboside,9-beta-d-ribofuranosyladenine
CAS Number: 58-61-7
DESCRIPTION
What It Does: Reduces fine lines, stimulates collagen, firms skin, and reduces inflammation.
Why It's Used: Fda-recognized anti-wrinkle active with multi-action collagen stimulation + wrinkle reduction + anti-inflammatory efficacy.
How It Works: Activates adenosine a2a receptors on fibroblasts stimulating collagen type i. also activates pka pathway promoting atp production and reducing inflammatory cytokines.
Typically Found In: Anti-aging serums,wrinkle treatments,korean skincare
TECHNICAL DETAILS
Primary Category: Active ingredient โ purine nucleoside / anti-aging
Secondary Functions: Collagen stimulation,anti-inflammatory,cell energy
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.04%โ0.1%
SOURCING & ETHICS
Vegan Status: Yes โ synthetically produced
Halal Status: Yes
Source Notes: Synthetically produced for cosmetic use.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; excellent tolerability.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. fda-recognized as safe and effective anti-wrinkle ingredient. ewg score: 1.
Works Well With: Other b vitamins,niacinamide,antioxidant complexes
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
A 2002 clinical study demonstrated 0.04% adenosine cream significantly reduced wrinkle depth and increased skin elasticity after 4 weeks. fda recognition requires controlled clinical trial evidence.
Last Verified: Cosing database,adenosine anti-aging clinical data,fda otc anti-wrinkle monograph
Primary Sources: 2026-03-12
Allantoin
Common Name(s): 5-ureidohydantoin,glyoxyldiureide,aluminum dihydroxy allantoinate
CAS Number: 97-59-6
DESCRIPTION
What It Does: Soothes irritation, accelerates wound healing, promotes skin cell renewal, and provides mild keratolytic exfoliation.
Why It's Used: Gold standard multi-function soothing active โ one of the most widely used cosmetic ingredients across all product types for its exceptional tolerability and clinically proven multi-action skin conditioning.
How It Works: Promotes keratinocyte proliferation and fibroblast migration for wound healing. mild keratolytic activity by disrupting corneocyte binding. anti-irritant via direct protein binding and anti-inflammatory cytokine reduction. humectant activity via hydroxyl groups.
Typically Found In: Post-procedure products,sensitive skin formulas,wound care,anti-acne treatments,baby products
TECHNICAL DETAILS
Primary Category: Active ingredient โ soothing / anti-inflammatory
Secondary Functions: Wound healing,keratolytic,anti-irritant
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ2%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic or comfrey-derived
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Exceptionally well-tolerated; suitable for all skin types including baby and compromised skin.
Safe for Sensitive Skin: Yes โ particularly recommended for sensitive skin
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Allantoin's keratinocyte proliferation stimulation occurs via receptor-mediated signaling (possibly machr activation) rather than non-specific irritation-driven proliferation, making it a true wound-healing stimulant rather than a pro-inflammatory proliferative signal.
Last Verified: Cosing database,cir safety assessment,araรบjo et al. allantoin review
Primary Sources: 2026-03-12
Ceramides
Common Name(s): Ceramides,ceramide sphingolipid,sc barrier lipid
CAS Number: N/a
DESCRIPTION
What It Does: Restores sc lamellar lipid bilayers, reduces trans-epidermal water loss, repairs barrier dysfunction in dry and eczematous skin, and strengthens the physical barrier against environmental irritants.
Why It's Used: Provides direct structural barrier lipid replacement โ unlike humectants that attract water, ceramides physically rebuild the lipid bilayer architecture required to retain moisture within the skin.
How It Works: Ceramides integrate into the sc intercellular lamellar bilayer, restoring the ordered orthorhombic packing disrupted in barrier-compromised skin. the sphingosine backbone's amide bond and hydroxyl groups form the h-bonding network that stabilises the lamellar structure.
Typically Found In: Barrier repair,dry skin,eczema-prone
TECHNICAL DETAILS
Primary Category: Functional ingredient โ emollient
Secondary Functions: Barrier sealing,softening
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ5%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Yes
Source Notes: Plant-derived, synthetic or animal-derived. verify source.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 1/5 โ low; formulation-dependent
Sensitivity Concerns: Non-irritating.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Humectants,ceramides,actives as carrier
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Sc ceramides comprise ~50% of the sc lipid mass (by weight) and are essential for barrier function; ceramide depletion in atopic dermatitis and aged skin is a primary driver of barrier dysfunction and tewl elevation.
Last Verified: Cosing database,ceramides ceramide barrier review
Primary Sources: 2026-03-12
Colloidal Oatmeal
Common Name(s): Colloidal oatmeal,cosmetic active,established function
CAS Number: N/a
DESCRIPTION
What It Does: Delivers characteristic cosmetic function โ skin conditioning, antioxidant protection, active biological benefit, or formulation function โ at recommended use concentration.
Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.
How It Works: Works through the mechanism of its molecular class โ physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.
Typically Found In: Skin care formulations
TECHNICAL DETAILS
Primary Category: Active ingredient โ cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ10%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Colloidal oatmeal has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.
Last Verified: Cosing database,colloidal oatmeal technical literature
Primary Sources: 2026-03-12