Bioderma
Bioderma Sensibio Defensive Rich Active Soothing Cream Hydration/Moisturisation 12h Nutrition (40 ml)
Bioderma Sensibio Defensive Rich Active Soothing Cream Hydration/Moisturisation 12h Nutrition (40 ml)
Bioderma
bioderma-sensibio-defensive-rich-active-soothing-cream-hydration-moisturisation-12h-nutrition-40-ml
Moisturize
10085492621605
Morning or Evening?
How often will you use this product?
Notes
Highlights
WHAT IS IT?
Soothing Cream with defensive technology, multi-ingredient, approx 5 main actives
FEATURES
Calms symptoms of sensitivity, strengthens skin self-defence, antioxidant protection, soothes double inflammation, fortifies barrier function
BEST FOR
sensitive
CHECKS
Fragrance-free, Paraben-Free, Alcohol-free (inferred from product type and brand positioning though not explicitly stated)
Who Is It For?
All Genders Suitable For Sensitive Skin No Specific Age MentionedWhat Does It Help With?
Sensitive Skin Inflammation Skin Protective Barrier StrengtheningBudget
Mid-range ($30-$75)How To Use
Which routine should it be used in?
Instructions:
Key Information
What Bioderma Says
Product Description:
Resulting from advanced Bioderma research DEFENSIVE TECHNOLOGY acts on these two types of sensitivity. This technology not only calms the symptoms associated with sensitivity but strengthens the selfdefence power of the skin and acts on the vicious circle of sensitive skin to provide longterm results antioxidant protective action with the combination of carnosine and vitamin E soothing action with polyphenols of red sage which act on double inflammation neurogenic and keratinocyte fortifying action of the barrier function to protect against attacks thanks to tetrapeptide10
About the Brand:
Ingredients Overview
Ingredients List
Key Ingredients
carnosine, vitamin-E, polyphenols-of-red-sage, tetrapeptide-10
Ingredients Details
Carnosine
Common Name(s): Beta-alanyl-l-histidine,n-beta-alanyl-l-histidine dipeptide
CAS Number: 305-84-0
DESCRIPTION
What It Does: Provides anti-glycation and anti-carbonylation activity protecting collagen from glycation-induced crosslinking.
Why It's Used: Natural anti-age dipeptide targeting glycation โ complementary to antioxidant-only anti-aging strategies with documented collagen protection.
How It Works: Histidine imidazole chelates cuยฒโบ for antioxidant metal chelation. beta-alanine traps reactive carbonyl species (glycating aldehydes). quenches 4-hydroxynonenal (hne) protein carbonylation. anti-glycation via competing with lysine residues.
Typically Found In: Anti-aging serums,anti-glycation products,longevity skincare
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ5%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Carnosine's anti-glycation mechanism is sacrificial carbonyl trapping: reactive carbonyl species (methylglyoxal, glyoxal) that would normally glycate collagen lysines are instead captured by carnosine's free amino groups โ carnosine acts as a sacrificial protector for collagen, being consumed in the process of preventing more damaging collagen glycation.
Last Verified: Cosing database,guiotto et al. carnosine anti-glycation review
Primary Sources: 2026-03-12
Tetrapeptide-10
Common Name(s): Tetrapeptide-10,tetrapeptide-10,signal peptide,anti-aging active
CAS Number: N/a
DESCRIPTION
What It Does: Provides tetrapeptide sequence-specific receptor binding to modulate collagen synthesis, elastin production, or barrier gene expression for measurable anti-aging outcomes.
Why It's Used: Tetrapeptide-10 delivers mechanism-based anti-aging activity through its specific amino acid pharmacophore โ the tetrapeptide length and sequence determining the precise receptor target and gene modulation pathway.
How It Works: Peptide spps synthesis โ sequence-specific receptor binding โ intracellular second messenger โ gene expression modulation โ collagen/elastin/barrier protein synthesis.
Typically Found In: Anti-aging,serum,eye care
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%โ2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Peptide stability requires ph 5.5โ6.5 and chelation of trace metals that catalyse oxidative chain cleavage.
Last Verified: Cosing database,tetrapeptide-10 signal peptide review
Primary Sources: 2026-03-22