Ceramidin™ Body Lotion Moisturizer

DESCRIPTION

What It Does: Provides alpha-hydroxy ceramide for complementary barrier repair alongside ceramide np and eop.

Why It's Used: Essential barrier ceramide trio component — ceramide ap's alpha-hydroxy fatty acid provides the specific lamellar body formation chemistry needed for complete barrier restoration with ceramide np and ceramide eop.

How It Works: N-(2-hydroxyfatty acid) phytosphingosine: 2-hydroxylation of fatty acid is critical for optimal packing of ceramide ap in lamellar lipid bilayers. the alpha-hydroxy group creates stronger intermolecular hydrogen bonding between ceramide ap molecules than non-hydroxylated ceramides. used in combination with ceramide np and ceramide eop for comprehensive barrier repair.

Typically Found In: Complete barrier repair formulas,triple ceramide systems,eczema treatment

TECHNICAL DETAILS

Primary Category: Active ingredient – alpha-hydroxy ceramide

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Conditional – plant-derived phytosphingosine available

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

The ceramide np + ceramide ap + ceramide eop triple combination mimics the natural ratio of ceramide classes in healthy stratum corneum (approximately 1:0.5:0.3 ratio). clinical studies comparing single ceramide vs triple ceramide barrier repair show significantly greater tewl reduction with triple ceramide combinations — the complementary molecular packing geometries of different ceramide classes creating a more complete lamellar bilayer than any single ceramide can provide.

Last Verified: Cosing database,elias & feingold barrier ceramide review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Restores sc lamellar lipid bilayers, reduces trans-epidermal water loss, repairs barrier dysfunction in dry and eczematous skin, and strengthens the physical barrier against environmental irritants.

Why It's Used: Provides direct structural barrier lipid replacement — unlike humectants that attract water, ceramides physically rebuild the lipid bilayer architecture required to retain moisture within the skin.

How It Works: Ceramides integrate into the sc intercellular lamellar bilayer, restoring the ordered orthorhombic packing disrupted in barrier-compromised skin. the sphingosine backbone's amide bond and hydroxyl groups form the h-bonding network that stabilises the lamellar structure.

Typically Found In: Barrier repair,dry skin,eczema-prone

TECHNICAL DETAILS

Primary Category: Functional ingredient – emollient

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%–5%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Sc ceramides comprise ~50% of the sc lipid mass (by weight) and are essential for barrier function; ceramide depletion in atopic dermatitis and aged skin is a primary driver of barrier dysfunction and tewl elevation.

Last Verified: Cosing database,ceramide as ceramide barrier review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the essential acylceramide scaffold for stratum corneum lamellar lipid organisation and barrier architecture.

Why It's Used: The architectural ceramide — ceramide eop's covalent corneocyte envelope binding is unique among ceramides and essential for organising the lamellar lipid matrix of the stratum corneum barrier.

How It Works: Omega-hydroxy ceramide esterified with linoleic acid at the omega-end. omega-hydroxyl group covalently bonds to involucrin/envoplakin proteins of corneocyte envelope via ester bond. this covalent anchor organises the lamellar lipid bilayers around each corneocyte. linoleate deficiency impairs this covalent anchoring — the biochemical basis of linoleic acid deficiency skin disease.

Typically Found In: Complete barrier repair systems,eczema treatment,omega-ceramide products

TECHNICAL DETAILS

Primary Category: Active ingredient – linoleate acylceramide

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.001%–0.5%

SOURCING & ETHICS

Vegan Status: Conditional – plant-derived linoleate available

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Ceramide eop's covalent corneocyte envelope binding is the only covalent interaction in the stratum corneum lipid structure — all other lamellar lipids interact via non-covalent van der waals and hydrogen bonds. this unique covalent anchoring of eop to the protein envelope provides the mechanical scaffold from which the entire lamellar lipid architecture is organised, making ceramide eop architecturally irreplaceable in barrier function.

Last Verified: Cosing database,holleran et al. ceramide eop review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the most abundant natural skin ceramide for precise stratum corneum barrier lipid replacement.

Why It's Used: The primary skin ceramide — ceramide np's identity as the dominant stratum corneum ceramide fraction makes it the most physiologically relevant barrier lipid replacement for dry skin and eczema.

How It Works: N-stearoyl-phytosphingosine provides the exact molecular structure of the most abundant natural skin ceramide. integrates into stratum corneum lamellar lipid bilayers restoring barrier architecture. reduces tewl, improves corneometer moisture, restores barrier integrity. synergistic with cholesterol and fatty acids in barrier restoration.

Typically Found In: Barrier repair moisturisers,eczema care,dry skin treatment

TECHNICAL DETAILS

Primary Category: Active ingredient – phytosphingosine ceramide

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%–5%

SOURCING & ETHICS

Vegan Status: Conditional – from wheat or phytosphingosine fermentation; plant-derived available

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Ceramide np's structural identity to natural skin ceramide 3 (the dominant sc ceramide at approximately 18% of total sc ceramide fraction) means it integrates into the stratum corneum's lamellar bilayer structure with perfect molecular recognition. no other moisturising ingredient can achieve this level of structural identity to the natural barrier component it replaces — providing barrier repair rather than simply occlusive surface coating.

Last Verified: Cosing database,elias skin barrier ceramide review,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Contributes to barrier lamellar body structure through unique hydrogen bonding capacity from 2-hydroxy fatty acid.

Why It's Used: Part of comprehensive ceramide barrier repair complexes providing the ceramide ns structural position in the lamellar body.

How It Works: 2-hydroxy fatty acid modification enables additional hydrogen bonding between adjacent ceramide headgroups in lamellar bilayers, contributing to barrier structural stability and impermeability.

Typically Found In: Ceramide complexes,barrier repair products

TECHNICAL DETAILS

Primary Category: Active ingredient – ceramide / barrier lipid

Secondary Functions: Barrier architecture,tewl reduction

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Conditional – synthetic or plant-derived; verify

Halal Status: Conditional – synthetic is halal; animal-derived verify

Source Notes: Synthetic or phytoceramides (wheat, konjac). verify source for vegan/halal.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Endogenous molecule; excellent tolerability.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. natural skin component. ewg score: 1.

Works Well With: Other ceramides,cholesterol,free fatty acids,hyaluronic acid,niacinamide

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

The 2-hydroxy fatty acid in ceramide ns participates in hydrogen bonding networks that increase the crystalline packing order of lamellar body bilayers. higher crystalline order correlates directly with lower tewl (transepidermal water loss) and superior barrier integrity.

Last Verified: Cosing database,elias ceramide review,bouwstra stratum corneum lipid structure

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides fatty alcohol emulsification and thickening for stable, well-textured emulsions.

Why It's Used: The most widely used fatty alcohol in cosmetics – provides emulsification, thickening, and emolliency simultaneously from a single ingredient with excellent safety profile.

How It Works: Forms bilayer lamellar structures in water with emulsifiers creating a viscous structured network that thickens and stabilizes emulsions. fatty alcohol emolliency provides direct skin conditioning. bilayer formation reduces inter-droplet coalescence in emulsions.

Typically Found In: Creams,lotions,conditioners – virtually all emulsion products

TECHNICAL DETAILS

Primary Category: Functional ingredient – fatty alcohol emulsifier/thickener

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–25%

SOURCING & ETHICS

Vegan Status: Yes – from vegetable or coconut/palm fatty acids

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Cetearyl alcohol's ability to form lamellar liquid crystal structures ('krafft phases') with water and co-emulsifiers provides not only emulsion stability but also enhanced skin penetration via the lamellar skin barrier pathway. these crystalline structures can act as a reservoir for active ingredients, slowly releasing them as the lamellar structure melts on skin contact.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the characteristic cosmetic function of its ingredient class through molecular chemistry at recommended use concentration.

Why It's Used: Cetyl ethylhexanoate is selected for the specific functional properties of its molecular class — the chemical architecture of cetyl ethylhexanoate delivers the required cosmetic performance through documented interactions with skin biology and formulation matrix.

How It Works: Functional groups interact with formulation and skin through h-bonding, ionic association, or receptor activity as appropriate.

Typically Found In: Cosmetic formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Safety documented in cosing at standard formulation concentrations.

Last Verified: Cosing database,cetyl ethylhexanoate technical review

Primary Sources: 2026-03-22

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30% (typical: 3–10%)

SOURCING & ETHICS

Vegan Status: Yes – plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes – when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides humectant moisture retention with antimicrobial preservative-boosting activity.

Why It's Used: The balanced multifunctional diol — pentylene glycol provides the ideal balance of humectancy and antimicrobial activity for clean beauty preservation systems with excellent sensory compatibility.

How It Works: C5 diol: longer chain than propylene glycol providing better antimicrobial activity but shorter than 1,2-hexanediol (slightly lower membrane activity). two oh groups provide humectant water binding. solvent for fragrances and some actives. synergistic with phenoxyethanol reducing required phenoxyethanol concentration.

Typically Found In: Clean beauty products,natural preservation systems,moisturisers

TECHNICAL DETAILS

Primary Category: Functional ingredient – multifunctional pentanediol

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–3%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pentylene glycol's position in clean beauty preservation is due to a regulatory quirk: 1,2-pentanediol is not classified as a preservative in eu cosmetics regulations (unlike phenoxyethanol which requires preservative listing), so it can provide antimicrobial activity while not requiring the 'contains preservative' designation — enabling cleaner labels in natural-positioned formulations.

Last Verified: Cosing database,dsm hydrolite-5 technical data,cir safety assessment

Primary Sources: 2026-03-12