Clinique Dramatically Different Moisturizing Lotion

DESCRIPTION

What It Does: Provides humectant hydration and active ingredient solubilization with excellent skin feel.

Why It's Used: Preferred glycol humectant in premium and k-beauty formulations for superior skin feel vs propylene glycol with equivalent functionality.

How It Works: Two hydroxyl groups at 1,3-positions provide water binding and solvent activity. better tolerated than propylene glycol with minimal sensitization risk. 4-carbon backbone provides slightly greater hydrophobic character enabling dissolution of less polar actives vs pg.

Typically Found In: Toners,essences,serums,k-beauty formulas

TECHNICAL DETAILS

Primary Category: Functional ingredient – glycol humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–10%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

K-beauty's preference for butylene glycol over propylene glycol is driven by two factors: bg's superior skin feel (less tacky than pg's higher viscosity) and its lower sensitization potential (1,3-bg has better spatial distribution of hydroxyl groups that reduces protein interaction vs pg's 1,2-position oh groups).

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antioxidant protection, anti-inflammatory activity, and skin conditioning from polyphenols, terpenoids, and phytochemicals in the extract.

Why It's Used: Natural plant extracts provide multi-functional phytochemical profiles supporting concurrent skin care claims from one ingredient with authentic botanical heritage.

How It Works: Polyphenols scavenge ros via h• donation; terpenoids inhibit nf-kb or cox inflammatory pathways; vitamins and minerals provide cofactor skin nutrition.

Typically Found In: Botanical skin care,natural products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–30%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Conditional

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Plant secondary metabolites evolved for uv photoprotection and pathogen defence — mechanisms directly applicable to cosmetic antioxidant and anti-inflammatory activity in human skin.

Last Verified: Cosing database,cucumis sativus (cucumber) fruit ex botanical review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30% (typical: 3–10%)

SOURCING & ETHICS

Vegan Status: Yes – plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes – when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides o/w emulsification with emolliency and skin feel improvement from a natural glycerol ester.

Why It's Used: Standard cosmetic monoglyceride emulsifier – widely used for o/w cream formation with clean, natural-origin credentials and good sensory profile.

How It Works: Monoglyceride structure (one fatty acid + glycerol) provides amphiphilic hlb ~3-4 for o/w emulsification when combined with higher hlb co-emulsifiers. forms alpha-gel lamellar structure with water for emulsion stabilization. direct skin conditioning via fatty acid film.

Typically Found In: Creams,lotions,moisturizers – standard in o/w emulsions

TECHNICAL DETAILS

Primary Category: Functional ingredient – monoglyceride emulsifier

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–10%

SOURCING & ETHICS

Vegan Status: Yes – from vegetable glycerol and stearic acid

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Glyceryl stearate's alpha-gel lamellar phase formation (distinguishable by x-ray crystallography from beta crystalline phase) provides superior emulsion stability compared to its beta crystalline form. the alpha-gel phase creates a viscoelastic network that resists droplet coalescence – the fundamental mechanism behind gms's long use as a reliable primary emulsifier.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Lanolin alcohol has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,lanolin alcohol technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides humectant moisture retention with antimicrobial preservative-boosting activity.

Why It's Used: The balanced multifunctional diol — pentylene glycol provides the ideal balance of humectancy and antimicrobial activity for clean beauty preservation systems with excellent sensory compatibility.

How It Works: C5 diol: longer chain than propylene glycol providing better antimicrobial activity but shorter than 1,2-hexanediol (slightly lower membrane activity). two oh groups provide humectant water binding. solvent for fragrances and some actives. synergistic with phenoxyethanol reducing required phenoxyethanol concentration.

Typically Found In: Clean beauty products,natural preservation systems,moisturisers

TECHNICAL DETAILS

Primary Category: Functional ingredient – multifunctional pentanediol

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–3%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pentylene glycol's position in clean beauty preservation is due to a regulatory quirk: 1,2-pentanediol is not classified as a preservative in eu cosmetics regulations (unlike phenoxyethanol which requires preservative listing), so it can provide antimicrobial activity while not requiring the 'contains preservative' designation — enabling cleaner labels in natural-positioned formulations.

Last Verified: Cosing database,dsm hydrolite-5 technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the highest level of skin occlusion and wound healing protection of any cosmetic ingredient.

Why It's Used: The most effective skin barrier protection ingredient available – fda-approved otc skin protectant with unparalleled occlusive moisturization and wound healing evidence.

How It Works: Semi-solid blend of long-chain hydrocarbons creates an extremely cohesive, impermeable occlusive film. physically prevents bacterial and irritant ingress while completely preventing tewl. does not absorb into skin. promotes moist wound healing environment by maintaining wound surface hydration.

Typically Found In: Intensive moisturizers,wound healing ointments,lip balms,baby products,eczema treatments

TECHNICAL DETAILS

Primary Category: Functional ingredient – petroleum ointment base / gold-standard occlusive

Secondary Functions: Maximum occlusion,wound healing,otc skin protectant

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–100%

SOURCING & ETHICS

Vegan Status: Yes – petroleum-derived

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic (clinical evidence)

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Fda category i grase otc skin protectant. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Petrolatum's wound healing mechanism (moist wound healing) was first systematically studied by george winter (1962) and demonstrated that wounds heal 2× faster under occlusion than air-exposed. all subsequent wound dressings and occlusive skin treatments are based on this fundamental finding, with petrolatum remaining the most effective occlusive agent 60 years later.

Last Verified: Cosing database,fda otc skin protectant monograph,winter (1962) moist wound healing study

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Prevents microbial contamination and spoilage in cosmetic formulations.

Why It's Used: The benchmark cosmetic preservative – eu-permitted up to 1%, effective against virtually all cosmetically relevant microorganisms, and excellent tolerability.

How It Works: Phenol ring provides broad antimicrobial activity via disruption of bacterial and fungal cell membranes and inhibition of enzymatic activity. effective against gram-positive and gram-negative bacteria, yeasts (candida), and molds (aspergillus). activity ph range: 3-9.

Typically Found In: All cosmetic formulations as primary preservative

TECHNICAL DETAILS

Primary Category: Functional ingredient – broad-spectrum preservative

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–1% (eu max 1%)

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu cosmetics regulation max 1%. sccs assessed as safe at ≤1%. avoid use around eyes in baby products per some country regulations. ewg score: 4.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Phenoxyethanol's widespread adoption as the primary cosmetic preservative followed the phaseout of parabens from many formulations in the 2000s-2010s. despite having a comparable or better safety profile to parabens, it is often cited in 'free-from' formulations – a consumer perception issue rather than a scientific safety concern.

Last Verified: Cosing database,sccs opinion on phenoxyethanol,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides emollient conditioning with spreading value determined by the ester molecular architecture.

Why It's Used: Propylene glycol dicaprate is selected for the specific functional properties of its molecular class — the chemical architecture of propylene glycol dicaprate delivers the required cosmetic performance through documented interactions with skin biology and formulation matrix.

How It Works: Ester: acid chain → emolliency type; alcohol chain → spreading speed and skin feel.

Typically Found In: Cosmetic formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Safety documented in cosing at standard formulation concentrations.

Last Verified: Cosing database,propylene glycol dicaprate technical review

Primary Sources: 2026-03-22

DESCRIPTION

What It Does: Provides hyaluronic acid hydration in the most formulation-stable and compatible form.

Why It's Used: The standard form of ha used in cosmetics – more stable than free ha, better solubility, and equivalent skin hydration benefits.

How It Works: Sodium salt reduces the polyelectrolyte repulsion of ha chains, allowing better packing in formulations. on skin, sodium ions dissociate and the ha chain unfolds to its full water-binding conformation. provides full ha humectant and barrier benefits equivalent to free ha.

Typically Found In: Hydrating serums,toners,moisturizers,sheet masks,anti-aging products

TECHNICAL DETAILS

Primary Category: Active ingredient – ha sodium salt

Secondary Functions: Equivalent ha hydration,superior stability

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – bacterial fermentation

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

The sodium salt form of ha has approximately 10% better water solubility than free hyaluronic acid at equivalent molecular weight due to reduced chain-chain electrostatic repulsion from partial sodium counterion screening. this improved solubility enables higher concentration formulations without viscosity issues.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12