Deep Hydration 48 Hour Activation Serum

Cetaphil

Deep Hydration 48 Hour Activation Serum

Deep Hydration 48 Hour Activation Serum

Cetaphil

deep-hydration-48-hour-activation-serum

Serum

9643551359269

Morning or Evening?

Morning
Evening
Both

How often will you use this product?

Everyday
Every other day
Every 3 days
Every 4 days
Every 5 days
Every 6 days
Once a week
Twice a week
On specific days
As needed
On rotation

Notes

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Compatibility Score

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Highlights

WHAT IS IT?

Hydrating serum with multiple ingredients

FEATURES

This lightweight serum instantly absorbs by deeply replenishing skin's hydration for 48 hours and improving the overall quality of sensitive skin.

BEST FOR

Dry or dehydrated, sensitive skin

CHECKS

Does not contain fragrance

Who Is It For?

Not Specified Suitable For Adults With Sensitive Skin

What Does It Help With?

Dryness Dehydration Skin Sensitivity

Budget

Affordable

How To Use

Which routine should it be used in?

Morning
Evening
 
Cleanse
Tone
Eyecare
Serum
Moisturize
Suncare
 

Instructions:

Use every morning and night after cleansing, gently smoothing over face and neck.

Key Information

Vegan
Cruelty-free
Sensitive-safe
Non-comedogenic
Hypoallergenic
Microbiome-safe
Preservative-free
Eco-friendly
Pregnancy-safe
Oil-free

What Cetaphil Says

Product Description:

This lightweight serum instantly absorbs by deeply replenishing skin's hydration for 48 hours and improving the overall quality of sensitive skin. Formulated with Hyaluronic Acid plus sunflower seed oil to immediately smooth the skin's texture and restores skin's radiant appearance.

About the Brand:

For over 70 years, Cetaphil has been the go-to brand for dermatologist-recommended skincare. Founded on the principle that effective skincare doesn't have to be complicated, Cetaphil offers a range of gentle, non-irritating products suitable for even the most sensitive skin. Discover the power of simplicity in achieving healthy, balanced skin.

Ingredients Overview

Ingredients List

Water, Glycerin, Sorbitol, Coco-Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Helianthus Annuus (Sunflower) Seed Oil, Octyldodecanol, Hexyldecanol, Hexyldecyl Laurate, Distarch Phosphate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Butyrospermum Parkii(Shea)Oil, Citric Acid, Dicaprylyl Carbonate, Disodium Cocoyl Glutamate, Globulariaalypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Panthenol (Vitamin B5), Pantolactone, Phenoxyethanol, Propylene Glycol, Sodium Benzoate, Sodium Hydroxide, Sodium Polyacrylate, Tocopherol (Vitamin E), Tocopheryl Acetate (Vitamin E Acetate), Xylitol, Xylitylglucoside

Key Ingredients

Hyaluronic Acid, Sunflower seed oil, Blue daisy, Vitamin B5, Vitamin E

Ingredients Details

Coco Caprylate/caprate

Common Name(s): Coco caprylate/caprate

DESCRIPTION

What It Does: Smooths and softens skin by filling intercorneocyte spaces, reducing friction, and providing a pleasant aesthetic skin feel in formulations.

Why It's Used: Synthetic esters provide tailored aesthetic properties โ€” spreadability, skin feel, volatility, refractive index โ€” that natural oils alone cannot consistently deliver.

How It Works: The ester molecule fills microscopic surface irregularities between corneocytes, reducing coefficient of friction, reflecting light uniformly, and providing a lubrication layer that protects the skin surface.

Typically Found In: Moisturizers,sunscreens,color cosmetics,body lotions,lip products

TECHNICAL DETAILS

Primary Category: Synthetic emollients

Secondary Functions: Emollient

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1โ€“20%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced ester emollient; no animal components.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 1

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Silicones,uv filters,other emollients

Avoid Combining With: Strongly alkaline conditions (risk of saponification of ester-type emollients)

SCIENTIFIC NOTE

The spreading coefficient of an emollient is governed by its surface tension, viscosity, and polarity. esters with branched alkyl chains (e.g., isopropyl, isostearyl) spread rapidly and leave a non-tacky film; linear long-chain esters provide more substantive moisturization. hlb value determines the preferred formulation system (w/o vs o/w emulsions).

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature

Primary Sources: 2025-01-15

Distarch Phosphate

Common Name(s): Distarch phosphate,natural biopolymer,film-former texture absorbent

CAS Number: N/a

DESCRIPTION

What It Does: Distarch phosphate absorbs surface sebum and cosmetic oils through its porous granule structure, provides a silky soft-focus powdery finish on skin from the biopolymer particle's low friction coefficient, forms a breathable protective film on skin and hair, and acts as an excipient carrier or encapsulation matrix for actives in powder formulations.

Why It's Used: Formulators choose distarch phosphate as a biodegradable, renewable alternative to synthetic polymers (ptfe, nylon, polyethylene) in powder cosmetics โ€” providing equivalent or superior absorbency and skin feel without microplastic regulatory concerns under eu regulation 2023/2055. natural starch granules have an intrinsically soft, semi-crystalline structure (mohs hardness ~1) that spreads smoothly on skin without abrasion, making them preferred over silica or talc when maximum gentleness is required. modified versions (cross-linked, esterified) extend the range of performance from pure powder through gel-forming to film-forming applications.

How It Works: Distarch phosphate works through the physical properties of its semicrystalline polysaccharide granule architecture: (1) oil absorption โ€” starch granules are semicrystalline spheres (amylose crystalline domains surrounded by amorphous amylopectin matrix) with a porous surface and internal channels. surface sebum and oil penetrate the granule via capillary action into these channels and are immobilised by van der waals forces with the polysaccharide chains โ€” providing oil-mattifying at the skin surface; (2) soft-focus texture โ€” granule diameter (5โ€“50 ฮผm, depending on source) and smooth spherical morphology provide low-friction glide between skin surface and the applying finger/brush, with the semicrystalline granule structure being soft enough to deform without sharp edges; (3) film formation โ€” when wetted, starch granules gelatinise (crystalline structure melts to amorphous hydrogel) above 60ยฐc during processing, cooling to form a continuous film. modified starches with crosslinks maintain film integrity without complete gelatinisation; (4) biodegradation โ€” amylase enzymes in soil rapidly hydrolyse the ฮฑ-1,4 and ฮฑ-1,6 glycosidic bonds, providing complete mineralisation to coโ‚‚ and water โ€” zero environmental persistence compared to synthetic polymer particles.

Typically Found In: Powders,dry shampoos,biodegradable cosmetics

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%โ€“30%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ€“2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Starch granule oil absorption capacity: oil absorption capacity (oac) of biopolymer powders correlates with granule porosity and internal surface area. rice starch (3โ€“8 ฮผm granules, high surface area) oac ~1.0 g oil/g; tapioca starch (15โ€“35 ฮผm, lower surface area) oac ~0.8 g/g; corn starch (10โ€“25 ฮผm) oac ~0.9 g/g. cross-linked modified starches maintain granule integrity under mechanical stress providing higher effective oac in use conditions. silica (oac ~2.5 g/g) outperforms starches on pure absorbency but the skin feel advantage of the softer biopolymer โ€” particularly the non-abrasive, cushioned texture โ€” justifies the lower oac for sensitive skin powders.

Last Verified: Cosing database,starch biopolymer cosmetic application review

Primary Sources: 2026-03-12

Glycerin

Common Name(s): Glycerol,glycerine,1,2,3-propanetriol

CAS Number: 56-81-5

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“30% (typical: 3โ€“10%)

SOURCING & ETHICS

Vegan Status: Yes โ€“ plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes โ€“ when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

Glyceryl Citrate/lactate/linoleate/oleate

Common Name(s): Glyceryl citrate/lactate/linoleate/oleate,multi-acid glycerol ester,natural glyceryl emulsifier

DESCRIPTION

What It Does: Helps oil and water blend naturally and supports skin's protective barrier.

Why It's Used: A naturally-derived complex emulsifier using multiple plant-origin acids (citric, lactic, linoleic, oleic) esterified on glycerol; suitable for natural and organic formulations.

How It Works: Multi-acid esterification creates an amphiphilic glyceryl ester with mixed hlb; linoleate and oleate tails provide oil-phase anchoring; citrate and lactate arms add hydrophilicity; ahas contribute gentle exfoliation potential.

Typically Found In: Natural cosmetics,organic formulations,skin barrier creams,natural emulsion systems

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ emulsifier

Secondary Functions: Skin conditioning,emollient,moisturizing

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%โ€“5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: All components from plant/fermentation origin (citric acid from fermentation, lactic acid from fermentation, linoleic/oleic from vegetable oils, glycerol from plant); fully natural.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 1/5 โ€“ low

Sensitivity Concerns: Generally well tolerated; rare aha-related sensitivity possible.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Natural oils,plant butters,other natural emulsifiers,humectants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Complex glyceryl esters incorporating aha (alpha-hydroxy acid) components (citrate/lactate) are part of the natural emulsifier trend replacing synthetic peg emulsifiers in certified organic cosmetics; the mixed fatty acid composition (linoleate + oleate) mirrors the skin's natural fatty acid profile.

Last Verified: Cosing database,inci dictionary,supplier technical data

Primary Sources: 2026-03-27