DERMATOUCH Bye Bye Pigmentation Face Wash || Anti Pigmentation Face Wash for Women/Men with Niacinamide, Kojic Acid, & Glutathione -30G

DESCRIPTION

What It Does: Soothes irritation, accelerates wound healing, promotes skin cell renewal, and provides mild keratolytic exfoliation.

Why It's Used: Gold standard multi-function soothing active – one of the most widely used cosmetic ingredients across all product types for its exceptional tolerability and clinically proven multi-action skin conditioning.

How It Works: Promotes keratinocyte proliferation and fibroblast migration for wound healing. mild keratolytic activity by disrupting corneocyte binding. anti-irritant via direct protein binding and anti-inflammatory cytokine reduction. humectant activity via hydroxyl groups.

Typically Found In: Post-procedure products,sensitive skin formulas,wound care,anti-acne treatments,baby products

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Wound healing,keratolytic,anti-irritant

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – synthetic or comfrey-derived

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Exceptionally well-tolerated; suitable for all skin types including baby and compromised skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Allantoin's keratinocyte proliferation stimulation occurs via receptor-mediated signaling (possibly machr activation) rather than non-specific irritation-driven proliferation, making it a true wound-healing stimulant rather than a pro-inflammatory proliferative signal.

Last Verified: Cosing database,cir safety assessment,araújo et al. allantoin review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the specific b-vitamin's characteristic skin and hair benefits: brightening and barrier reinforcement (niacinamide), keratin structural support (biotin), deep conditioning humectancy (panthenol).

Why It's Used: B-vitamins operate through fundamental cellular biochemistry pathways — nad⁺ for niacinamide, carboxylase cofactor for biotin, coa synthesis for panthenol — providing multi-benefit activity from essential metabolic chemistry.

How It Works: Acts as coenzyme or substrate in essential metabolic pathways: niacinamide → nad⁺/nadp⁺ → ceramide synthesis, melanosome transfer inhibition; biotin → carboxylase → fatty acid synthesis for ceramide; panthenol → pantothenic acid → coa → lipid metabolism.

Typically Found In: Multi-function skin care,b-vitamin formulas

TECHNICAL DETAILS

Primary Category: Active ingredient – vitamin b complex

Secondary Functions: Antioxidant cofactor,metabolic support

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced for cosmetic use.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; excellent tolerability.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Other b vitamins,niacinamide,antioxidant complexes

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

B-vitamins are water-soluble, non-irritating, and well-tolerated across all skin types — providing clinical efficacy with an exceptional safety profile from their essential nutrient status.

Last Verified: Cosing database,d-panthenol b-vitamin skin review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides metal ion chelation to prevent product degradation and boost preservative and antioxidant efficacy.

Why It's Used: The most essential stability ingredient in cosmetics — disodium edta's metal chelation prevents rancidity, discoloration, and preservative failure caused by trace metal contamination in virtually all aqueous cosmetic formulations.

How It Works: Ethylenediaminetetraacetic acid provides six potential coordination sites for metal ions (aminodiacetate groups). chelates ca²⁺, mg²⁺ (stability), fe³⁺ (fenton radical prevention), cu²⁺ (oxidase inhibition). disrupts gram-negative bacterial outer membrane by chelating membrane calcium, enhancing preservative penetration.

Typically Found In: Virtually all aqueous cosmetics — creams, lotions, shampoos, toners

TECHNICAL DETAILS

Primary Category: Functional ingredient – chelating agent

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.005%–0.1%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Disodium edta's preservative potentiation against gram-negative bacteria is mechanistically elegant: gram-negative outer membranes contain lipopolysaccharide stabilised by calcium and magnesium bridges. edta chelates these metal ions, destabilising the lps layer and creating pores that allow hydrophobic preservatives (phenoxyethanol, parabens) to penetrate — converting gram-negative-resistant preservatives into broad-spectrum ones.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the body's primary antioxidant defense while reducing melanin production for brightening.

Why It's Used: Master antioxidant for comprehensive oxidative stress protection alongside unique melanin-shifting brightening action (pheomelanin preference).

How It Works: Three-amino acid tripeptide (gamma-glu-cys-gly). thiol group (-sh) provides electron donation for antioxidant activity and detoxification conjugation. shifts melanin synthesis from eumelanin (dark brown) toward pheomelanin (light yellow-red) for brightening. regenerates vitamins c and e from their oxidized forms.

Typically Found In: Brightening serums,antioxidant serums,anti-aging products

TECHNICAL DETAILS

Primary Category: Active ingredient – master cellular antioxidant

Secondary Functions: Melanin shifting brightening,vitamins c+e regeneration,master antioxidant

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes – fermentation-derived

Halal Status: Yes

Source Notes: Produced by yeast fermentation or chemical synthesis. stability challenge – use encapsulated or stabilized forms.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated; some reports of tingling at high concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Glutathione's melanin-shifting mechanism (eumelanin→pheomelanin) is entirely different from tyrosinase inhibition. even in the presence of active tyrosinase, glutathione shifts the enzymatic product from dark eumelanin to lighter pheomelanin by chelating copper from the tyrosinase active site and competing for dopa substrate.

Last Verified: Cosing database,villarama & maibach glutathione brightening review,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Attracts and retains moisture in the sc, improves skin barrier function at low concentrations, provides gentle keratolytic softening, and acts as a co-solvent for water-soluble actives.

Why It's Used: The reference humectant — lowest cost, best safety profile, universal formulation compatibility, and present naturally in the sc via lipase-mediated glycerolipid hydrolysis makes glycerin the industry standard against which all humectants are benchmarked.

How It Works: Three hydroxyl groups form 6 h-bonds with water molecules per glycerol unit — the highest oh-group density per carbon of any commercial humectant. glycerin also down-regulates epidermal serine proteases that overactivate in dry sc, improving desquamation and barrier integrity.

Typically Found In: All cosmetics,universal

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–40%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Epidermal lipases hydrolyse sc glycerophospholipids during cornification, releasing glycerol that contributes to the natural nmf — topical glycerin directly supplements this endogenous sc humectant pool.

Last Verified: Cosing database,glycerin universal humectant review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides maximum aha efficacy from the smallest most penetrating alpha-hydroxy acid.

Why It's Used: The most potent aha — glycolic acid's smallest molecular size provides the deepest penetration and highest efficacy of any alpha-hydroxy acid for exfoliation and anti-aging.

How It Works: Smallest aha (mw 76) provides deepest stratum corneum penetration. disrupts corneodesmosomes reducing cohesion. stimulates fibroblast collagen i and iii synthesis. efficacy is ph-dependent — free acid fraction determines activity.

Typically Found In: Chemical peels,body lotions,anti-aging serums,exfoliating toners

TECHNICAL DETAILS

Primary Category: Active ingredient – primary aha

Secondary Functions: Brightening,collagen stimulation

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–10% cosmetic; higher professional

SOURCING & ETHICS

Vegan Status: Yes – synthetic or fermentation-derived

Halal Status: Yes

Source Notes: Fermentation-derived or synthetic. ph must be ≤4.0 for aha activity.

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Photosensitizing – mandatory spf use. start at low frequency.

Safe for Sensitive Skin: Use with caution – spf required

SAFETY & COMPATIBILITY

Safety Profile: Eu cosmetics: max 10% leave-on, ph ≥3.5, mandatory sun protection advisory. professional peel concentrations regulated separately.

Works Well With: Niacinamide,ceramides,hyaluronic acid,spf

Avoid Combining With: Retinol in same step; multiple exfoliants simultaneously

SCIENTIFIC NOTE

Glycolic acid's ph-dependent efficacy is critical: at ph 3.0 ~100% is in the free acid (membrane-permeable) form; at ph 3.5 ~70%; at ph 4.0 ~50%. the eu ph ≥3.5 requirement reduces free acid proportion, lowering efficacy but also reducing irritation — why professional peel concentrations at lower ph are far more active than equivalent cosmetic concentrations.

Last Verified: Cosing database,eu aha guidelines,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Exfoliates dead skin cells, attracts and retains moisture, brightens skin tone, and improves texture.

Why It's Used: Dual exfoliant and humectant – uniquely hydrating vs other ahas. gentler and suitable for normal-to-sensitive skin.

How It Works: Disrupts desmosomes to promote exfoliation at low ph. acts as humectant. also stimulates ceramide synthesis at lower concentrations for barrier support.

Typically Found In: Chemical exfoliants,toners,serums,professional peels

TECHNICAL DETAILS

Primary Category: Active ingredient – alpha hydroxy acid (aha)

Secondary Functions: Humectant,brightening,barrier support,ceramide synthesis

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 2%–10% (daily); 20%–90% (professional); active at ph ≤3.9

SOURCING & ETHICS

Vegan Status: Yes – synthetic or fermentation-derived

Halal Status: Yes

Source Notes: Fermentation-derived from carbohydrates or synthetically produced. both l-form and dl-form used.

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Photosensitizing – spf required. better tolerated than glycolic acid for most skin types.

Safe for Sensitive Skin: Use with caution – spf required

SAFETY & COMPATIBILITY

Safety Profile: Safe at otc concentrations. eu: ≤10% leave-on at ph ≥3.5. mandatory spf advisory.

Works Well With: Niacinamide,ceramides,hyaluronic acid,spf

Avoid Combining With: Retinol in same step; multiple exfoliants simultaneously

SCIENTIFIC NOTE

Lactic acid's role as a natural moisturizing factor (nmf) component makes it uniquely hydrating among ahas. ceramide synthesis stimulation at 2% provides barrier benefits complementing exfoliating activity.

Last Verified: Cosing database,stiller et al. lactic acid review,sccs aha opinion

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antimicrobial c12 fatty acid activity against p. acnes and skin pathogens alongside emollient conditioning.

Why It's Used: Antimicrobial emollient with documented anti-acne activity through p. acnes membrane disruption – the primary antimicrobial fatty acid in human breast milk and coconut oil.

How It Works: C12 chain length is optimal for antimicrobial fatty acid activity: long enough for membrane insertion but short enough for effective disruption. disrupts p. acnes lipid membrane. converts to monolaurin (antimicrobial monoglyceride) via skin esterases. low melting point (44°c) provides liquid-phase emolliency above skin temperature.

Typically Found In: Anti-acne products,antimicrobial skin care,coconut-based products

TECHNICAL DETAILS

Primary Category: Functional ingredient – c12 medium chain fatty acid

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–10%

SOURCING & ETHICS

Vegan Status: Yes – from coconut (cocos nucifera)

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 4/5 – moderate to high comedogenic potential

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Lauric acid's antimicrobial activity against p. acnes (ic50 ~1μg/ml) exceeds benzoyl peroxide's ic50 (~50μg/ml) by approximately 50-fold in in vitro studies, making it one of the most potent naturally occurring anti-p. acnes compounds. its high comedogenicity rating (4/5) presents the paradox of a powerful anti-acne active in a comedogenic vehicle – limiting its practical anti-acne formulation use.

Last Verified: Cosing database,nakatsuji et al. lauric acid anti-acne study,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Myristic acid has an established safety profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,myristic acid technical literature

Primary Sources: 2026-03-12