Fixderma
Fixderma 2% Niacinamide Face 21 Cream
Fixderma 2% Niacinamide Face 21 Cream
Fixderma
fixderma-2-niacinamide-face-21-cream
Moisturize
10084856725797
Morning or Evening?
How often will you use this product?
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Highlights
WHAT IS IT?
Face Moisturizer & Day Cream, Contains multifunctional actives including 4 key actives
FEATURES
Reduces uneven skin tone, wrinkles and fine lines, brightens skin, reduces pigmentation and dark spots, illuminates dull skin, non-greasy, lightweight, non-comedogenic, suitable for all skin types, paraben-free, vegan and cruelty-free
BEST FOR
normal
CHECKS
Does not contain parabens
Who Is It For?
All Genders No Specific Age Range MentionedWhat Does It Help With?
Uneven Skin Tone Wrinkles Fine Lines Dullness Pigmentation Dark SpotsBudget
Affordable (under $30)How To Use
Which routine should it be used in?
Instructions:
Key Information
What Fixderma Says
Product Description:
Fixderma Face21 Face Cream is a special combination with multiple benefits, like reducing uneven skin tone, wrinkles, and fine lines. Dullness is a major skin concern, which is taken care of by Face21 cream's skin-brightening and skin-polishing actives. The formulation is non-greasy and non-comedogenic. This cream is a skin-brightening and glowing formulation that contains multifunctional actives. Features include face cream for daily use, enriched with willow herb extract, alpha-arbutin, kakadu plum, omega plus, and bio-retinol. Brightens the skin, reduces pigmentation and dark spots, illuminates dull skin, non-greasy and lightweight, non-comedogenic, suitable for all skin types, free of parabens, vegan and cruelty-free.
About the Brand:
Ingredients Overview
Ingredients List
alpha-arbutin,kakadu-plum,omega-plus,bio-retinol
Key Ingredients
Alpha Arbutin, Kakadu Plum, Omega Plus, Bio Retinol
Ingredients Details
Alpha-arbutin
Common Name(s): 4-hydroxyphenyl-alpha-d-glucopyranoside
DESCRIPTION
What It Does: Provides potent tyrosinase inhibition with improved stability and tolerability over other arbutin forms.
Why It's Used: Premium arbutin โ alpha configuration provides 10ร greater tyrosinase inhibition than beta-arbutin at equivalent concentration, making alpha-arbutin the most effective arbutin form.
How It Works: Alpha-glucoside linkage provides enhanced metabolic stability vs beta-arbutin (less enzymatic hydrolysis to free hydroquinone in skin). inhibits tyrosinase via competitive substrate inhibition (ic50 ~24ฮผg/ml vs beta-arbutin ~525ฮผg/ml โ 20ร more potent). inhibits dopa oxidase step in melanogenesis.
Typically Found In: Brightening serums,anti-spot products,premium lightening
TECHNICAL DETAILS
Primary Category: Active ingredient โ arbutin brightening agent
Secondary Functions: Melanin inhibition,hyperpigmentation reduction
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ2%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic enzymatic synthesis
Halal Status: Yes
Source Notes: Synthetic or plant-derived.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. use with spf for maximum efficacy. ewg score: 1.
Works Well With: Niacinamide,vitamin c,alpha-arbutin,tranexamic acid,spf
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Alpha-arbutin's 10โ20ร greater potency vs beta-arbutin at equivalent concentration arises from the alpha-glycosidic bond geometry โ the alpha configuration positions the hydroquinone aglycone at a specific orientation relative to the glucose that fits the tyrosinase active site copper more precisely than the beta isomer's different spatial arrangement.
Last Verified: Cosing database,sugimoto et al. arbutin tyrosinase study
Primary Sources: 2026-03-12