Fixderma Daily Moisturizing Cream For Hydration and Moisturization, NonComedogenic & NonGreasy

DESCRIPTION

What It Does: Soothes irritation, accelerates wound healing, promotes skin cell renewal, and provides mild keratolytic exfoliation.

Why It's Used: Gold standard multi-function soothing active – one of the most widely used cosmetic ingredients across all product types for its exceptional tolerability and clinically proven multi-action skin conditioning.

How It Works: Promotes keratinocyte proliferation and fibroblast migration for wound healing. mild keratolytic activity by disrupting corneocyte binding. anti-irritant via direct protein binding and anti-inflammatory cytokine reduction. humectant activity via hydroxyl groups.

Typically Found In: Post-procedure products,sensitive skin formulas,wound care,anti-acne treatments,baby products

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Wound healing,keratolytic,anti-irritant

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – synthetic or comfrey-derived

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Exceptionally well-tolerated; suitable for all skin types including baby and compromised skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Allantoin's keratinocyte proliferation stimulation occurs via receptor-mediated signaling (possibly machr activation) rather than non-specific irritation-driven proliferation, making it a true wound-healing stimulant rather than a pro-inflammatory proliferative signal.

Last Verified: Cosing database,cir safety assessment,araújo et al. allantoin review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides a dry, weightless application vehicle that evaporates cleanly leaving actives and non-volatile silicones deposited on skin — eliminating the residual heaviness of conventional liquid carrier solvents.

Why It's Used: Cyclosiloxanes are the unique volatile silicone solvents that dissolve non-volatile silicones (dimethicone, cyclomethicone), organic uv filters, and lipophilic actives, providing the sensory-superior dry-touch application experience in premium formulations.

How It Works: Cyclosiloxane vapour pressure (d5 cyclopentasiloxane ~0.3 mmhg at 25°c) provides clean evaporation at body temperature. the cyclic ring structure provides lower boiling point than equivalent linear dimethicone, enabling faster evaporation while the ring conformation maintains the silicone's low surface energy for smooth application.

Typically Found In: Primers,antiperspirants,sunscreens

TECHNICAL DETAILS

Primary Category: Functional ingredient – emollient

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–50%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Cyclopentasiloxane (d5) and cyclohexasiloxane (d6) are under eu regulatory review for potential environmental persistence (pbt assessment) — formulators should monitor eu regulation 2018/35 implementation for restrictions in wash-off products.

Last Verified: Cosing database,eu cyclosiloxane regulatory review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antimicrobial skin conditioning with deodorant activity and preservation system enhancement.

Why It's Used: Multifunctional clean beauty preservation active — ethylhexylglycerin provides antimicrobial, deodorant, and skin conditioning in a single ingredient accepted in most natural cosmetic certification schemes.

How It Works: Glycerol ether provides antimicrobial via bacterial membrane phospholipid disruption. deodorant activity via reduction of underarm lipase enzyme activity (similar mechanism to triethyl citrate). skin conditioning from glycerol humectant component. synergistic with phenoxyethanol and diols.

Typically Found In: Natural preservation systems,deodorants,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – antimicrobial glycerol ether

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–0.5%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Ethylhexylglycerin's deodorant mechanism is pharmacologically identical to triethyl citrate: both inhibit skin surface microbial lipase enzymes that convert odourless triglycerides to odorous free fatty acids. the glycerol ether structure of ethylhexylglycerin, combined with the 2-ethylhexyl chain, provides lipase inhibition similar to ester-based lipase inhibitors from a different chemical class.

Last Verified: Cosing database,schülke sensiva sc 10 technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the complete fragrance profile contributing to product sensory experience and consumer appeal.

Why It's Used: Fragrance is a major consumer purchase driver — up to 70% of consumers make purchasing decisions partially based on product scent.

How It Works: Fragrance blends interact with olfactory receptors providing the sensory profile — complex mixtures activate multiple receptor types for rich, multidimensional scent experiences.

Typically Found In: All fragrance products

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: Standard use levels

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Ifra guidelines set usage limits for fragrance ingredients based on skin sensitisation and phototoxicity assessment for each application category.

Last Verified: Eu regulation 1223/2009 annex iii,ifra standards,fragrance allergen declaration requirements

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Attracts and retains moisture in the sc, improves skin barrier function at low concentrations, provides gentle keratolytic softening, and acts as a co-solvent for water-soluble actives.

Why It's Used: The reference humectant — lowest cost, best safety profile, universal formulation compatibility, and present naturally in the sc via lipase-mediated glycerolipid hydrolysis makes glycerin the industry standard against which all humectants are benchmarked.

How It Works: Three hydroxyl groups form 6 h-bonds with water molecules per glycerol unit — the highest oh-group density per carbon of any commercial humectant. glycerin also down-regulates epidermal serine proteases that overactivate in dry sc, improving desquamation and barrier integrity.

Typically Found In: All cosmetics,universal

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–40%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Epidermal lipases hydrolyse sc glycerophospholipids during cornification, releasing glycerol that contributes to the natural nmf — topical glycerin directly supplements this endogenous sc humectant pool.

Last Verified: Cosing database,glycerin universal humectant review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Prevents microbial contamination and spoilage in cosmetic formulations.

Why It's Used: The benchmark cosmetic preservative – eu-permitted up to 1%, effective against virtually all cosmetically relevant microorganisms, and excellent tolerability.

How It Works: Phenol ring provides broad antimicrobial activity via disruption of bacterial and fungal cell membranes and inhibition of enzymatic activity. effective against gram-positive and gram-negative bacteria, yeasts (candida), and molds (aspergillus). activity ph range: 3-9.

Typically Found In: All cosmetic formulations as primary preservative

TECHNICAL DETAILS

Primary Category: Functional ingredient – broad-spectrum preservative

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–1% (eu max 1%)

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu cosmetics regulation max 1%. sccs assessed as safe at ≤1%. avoid use around eyes in baby products per some country regulations. ewg score: 4.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Phenoxyethanol's widespread adoption as the primary cosmetic preservative followed the phaseout of parabens from many formulations in the 2000s-2010s. despite having a comparable or better safety profile to parabens, it is often cited in 'free-from' formulations – a consumer perception issue rather than a scientific safety concern.

Last Verified: Cosing database,sccs opinion on phenoxyethanol,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: At 2–10%: provides deep humectancy, softens sc, and improves other active penetration. at 10–40%: keratolytically dissolves corneocyte protein bonds for intensive exfoliation of hyperkeratotic skin (calluses, eczema plaques, psoriasis).

Why It's Used: Urea combines two otherwise separate ingredient classes (humectant and keratolytic) in one molecule, with formulator-controlled function through concentration selection — uniquely versatile for multiple skin condition applications.

How It Works: Urea's carbonyl and amine groups form h-bonds with water (humectancy) and with corneocyte keratin (penetration). at high concentrations, urea disrupts keratin hydrogen bonds (chaotropic activity) solubilising the sc protein matrix — concentration determines whether humectant or keratolytic effect predominates.

Typically Found In: Eczema,hyperkeratosis,callus care,moisturising

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 2%–40%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Urea is the most concentrated natural nmf component — healthy sc contains 28 mg/g urea versus 2 mg/g in xerotic (dry) skin. topical urea application directly replenishes the physiological nmf deficit that drives dry skin conditions.

Last Verified: Cosing database,urea nmf dual function humectant keratolytic review

Primary Sources: 2026-03-12