Fixderma
Fixderma Skarfix Tx Face Serum-30 ml
Fixderma Skarfix Tx Face Serum-30 ml
Fixderma
fixderma-skarfix-tx-face-serum-30-ml
Serum
10085469847845
Morning or Evening?
How often will you use this product?
Notes
Highlights
WHAT IS IT?
Face Serum with 2 key active ingredients
FEATURES
Targets pigmentation, dark spots, and uneven skin tone; contains Kojic Acid & Tranexamic Acid; brightens and evens skin; reduces appearance of scars and blemishes; noncomedogenic formula
BEST FOR
sensitive
CHECKS
Does not contain comedogenic ingredients
Who Is It For?
What Does It Help With?
Pigmentation Dark Spots Uneven Skin Tone Scars BlemishesBudget
Mid-range ($30-$75)How To Use
Which routine should it be used in?
Instructions:
Key Information
What Fixderma Says
Product Description:
Fixderma SkarfixTx Face Serum is a holistic approach to target pigmentation dark spots and uneven skin tone. Formulated with advanced ingredients like Kojic Acid & Tranexamic Acid it helps to brighten and even out skin while reducing the appearance of scars and blemishes. This noncomedogenic serum reveals smoother more evenly toned skin with each application.
About the Brand:
Ingredients Overview
Ingredients List
Key Ingredients
Kojic Acid,Tranexamic Acid
Ingredients Details
Kojic Acid
Common Name(s): 5-hydroxy-2-(hydroxymethyl)-4-pyranone,koji acid
CAS Number: 501-30-4
DESCRIPTION
What It Does: Provides potent copper-chelating tyrosinase inhibition for effective hyperpigmentation treatment.
Why It's Used: One of the most effective brightening agents โ kojic acid's copper chelation directly blocks the tyrosinase active site providing stronger brightening than most naturally-derived alternatives.
How It Works: Chelates copper in the tyrosinase active site via the 3-hydroxy-4-pyranone chelating group (ic50 ~5ฮผg/ml). without copper cofactor, tyrosinase cannot oxidise tyrosine to dopa or dopa to dopaquinone. inhibits both hydroxylation steps in eumelanin synthesis pathway.
Typically Found In: Brightening serums,hyperpigmentation treatments,anti-spot products
TECHNICAL DETAILS
Primary Category: Active ingredient โ fungal brightening agent
Secondary Functions: Melanin inhibition,hyperpigmentation reduction
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ2%
SOURCING & ETHICS
Vegan Status: Yes โ from aspergillus oryzae or acetobacter fermentation
Halal Status: Yes
Source Notes: Synthetic or plant-derived.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Eu annex iii regulated: max 1% in face products. sensitiser potential โ patch test for sensitive skin. photosensitive in formulation โ requires stabilisation.
Works Well With: Niacinamide,vitamin c,alpha-arbutin,tranexamic acid,spf
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Kojic acid's copper chelation mechanism provides an unusually direct enzyme inhibition: rather than competing with tyrosine substrate (competitive inhibitor) or altering enzyme conformation (allosteric inhibitor), kojic acid simply removes the copper cofactor that is essential for tyrosinase catalytic activity โ a metal-chelation mechanism that provides near-complete enzyme inhibition regardless of substrate concentration.
Last Verified: Cosing database,eu annex iii,cir safety assessment
Primary Sources: 2026-03-12
Tranexamic Acid
Common Name(s): Trans-4-aminomethylcyclohexanecarboxylic acid,txa,cyklokapron
CAS Number: 1197-18-8
DESCRIPTION
What It Does: Provides brightening by inhibiting uv-induced plasminogen activation that triggers melanocyte stimulation.
Why It's Used: Novel brightening mechanism โ tranexamic acid targets uv-induced melanocyte stimulation upstream of tyrosinase activity, providing complementary brightening to tyrosinase inhibitors with exceptional tolerability.
How It Works: Lysine analogue binds lysine-binding sites on plasminogen preventing its conversion to plasmin. uv-activated plasmin normally increases keratinocyte arachidonic acid release stimulating melanocyte activity via prostaglandin e2 and alpha-msh. txa blocks this uv-melanocyte signalling cascade upstream of pigment synthesis.
Typically Found In: Brightening serums,anti-melasma products,uv-induced pigmentation
TECHNICAL DETAILS
Primary Category: Active ingredient โ lysine analogue brightening
Secondary Functions: Melanin inhibition,hyperpigmentation reduction
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ5%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic
Halal Status: Yes
Source Notes: Synthetic or plant-derived.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. use with spf for maximum efficacy. ewg score: 1.
Works Well With: Niacinamide,vitamin c,alpha-arbutin,tranexamic acid,spf
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Tranexamic acid's brightening mechanism was discovered serendipitously โ it was originally a haemostasis drug for reducing surgical bleeding. dermatologists noted that patients receiving txa for bleeding showed improved melasma, leading to investigation that revealed the plasminogenโprostaglandinโmelanocyte signalling cascade as a completely previously unknown brightening target.
Last Verified: Cosing database,huang et al. tranexamic acid brightening review
Primary Sources: 2026-03-12