Gentle Clear Triple-Action Acne Serum

Cetaphil

Gentle Clear Triple-Action Acne Serum

Gentle Clear Triple-Action Acne Serum

Cetaphil

gentle-clear-triple-action-acne-serum

Serum

9643553423653

Morning or Evening?

Morning
Evening
Both

How often will you use this product?

Everyday
Every other day
Every 3 days
Every 4 days
Every 5 days
Every 6 days
Once a week
Twice a week
On specific days
As needed
On rotation

Notes

Add to Routine
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Compatibility Score

0%

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How It Fits Into Your Skincare Routine

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Highlights

WHAT IS IT?

Acne serum with 14 ingredients

FEATURES

Improves appearance of breakouts in 3 days, 24-hour hydration, resurfaces skin, improves uneven skin tone

BEST FOR

Breakout-prone, sensitive skin

CHECKS

Fragrance-free, paraben-free, won't clog pores

Who Is It For?

Not Specified Likely Suitable For Adults With Acne-prone Skin

What Does It Help With?

Acne Uneven Skin Tone Breakouts

Budget

Affordable

How To Use

Which routine should it be used in?

Morning
Evening
 
Cleanse
Tone
Eyecare
Serum
Moisturize
Suncare
 

Instructions:

Apply it to dampened skin and gently massage. Rinse thoroughly and pat dry.

Key Information

Vegan
Cruelty-free
Sensitive-safe
Non-comedogenic
Hypoallergenic
Microbiome-safe
Preservative-free
Eco-friendly
Pregnancy-safe
Oil-free

What Cetaphil Says

Product Description:

This milky-gel serum with 0.5% salicylic acid improves the appearance of breakouts in just 3 days. With 24-hour hydration, it is formulated with soothing succinic acid to resurface skin and improve the appearance of uneven skin tone.

About the Brand:

For over 70 years, Cetaphil has been the go-to brand for dermatologist-recommended skincare. Founded on the principle that effective skincare doesn't have to be complicated, Cetaphil offers a range of gentle, non-irritating products suitable for even the most sensitive skin. Discover the power of simplicity in achieving healthy, balanced skin.

Ingredients Overview

Ingredients List

Water, Glycerin, Coco-Caprylate/Caprate, Gluconolactone, Propanediol, Sodium Hydroxide, Succinic Acid, Panthenol, Niacinamide, Lysolecithin, Sclerotium Gum, Zinc Gluconate, Pullulan, Xanthan Gum, Pantolactone, Citric Acid, Silica

Key Ingredients

Salicylic Acid 0.5%, Succinic Acid

Ingredients Details

Coco Caprylate/caprate

Common Name(s): Coco caprylate/caprate

DESCRIPTION

What It Does: Smooths and softens skin by filling intercorneocyte spaces, reducing friction, and providing a pleasant aesthetic skin feel in formulations.

Why It's Used: Synthetic esters provide tailored aesthetic properties โ€” spreadability, skin feel, volatility, refractive index โ€” that natural oils alone cannot consistently deliver.

How It Works: The ester molecule fills microscopic surface irregularities between corneocytes, reducing coefficient of friction, reflecting light uniformly, and providing a lubrication layer that protects the skin surface.

Typically Found In: Moisturizers,sunscreens,color cosmetics,body lotions,lip products

TECHNICAL DETAILS

Primary Category: Synthetic emollients

Secondary Functions: Emollient

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1โ€“20%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced ester emollient; no animal components.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 1

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Silicones,uv filters,other emollients

Avoid Combining With: Strongly alkaline conditions (risk of saponification of ester-type emollients)

SCIENTIFIC NOTE

The spreading coefficient of an emollient is governed by its surface tension, viscosity, and polarity. esters with branched alkyl chains (e.g., isopropyl, isostearyl) spread rapidly and leave a non-tacky film; linear long-chain esters provide more substantive moisturization. hlb value determines the preferred formulation system (w/o vs o/w emulsions).

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature

Primary Sources: 2025-01-15

Gluconolactone

Common Name(s): D-gluconolactone,delta-gluconolactone

CAS Number: 90-80-2

DESCRIPTION

What It Does: Provides the gentlest chemical exfoliation with simultaneous antioxidant, moisture retention, and barrier support.

Why It's Used: Preferred exfoliant for rosacea, eczema, sensitive skin, and post-procedure recovery where standard ahas cause unacceptable irritation.

How It Works: Hydrolyzes slowly on skin surface to gluconic acid providing gentle exfoliation. multiple hydroxyl groups enable water binding (humectant) and metal chelation (antioxidant).

Typically Found In: Sensitive skin exfoliants,rosacea treatments,eczema care,post-procedure recovery

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ polyhydroxy acid (pha)

Secondary Functions: Gentle exfoliation,antioxidant,humectant

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 5%โ€“15%

SOURCING & ETHICS

Vegan Status: Yes โ€“ fermentation or synthetic

Halal Status: Yes

Source Notes: Fermentation-derived from glucose or synthetic. among the safest chemical exfoliants available.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: No photosensitization; no stinging; suitable for very sensitive skin.

Safe for Sensitive Skin: Yes โ€“ ideal for sensitive, reactive, rosacea, and eczema-prone skin; no photosensitization

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. no photosensitization. ewg score: 1.

Works Well With: Ceramides,niacinamide,hyaluronic acid,soothing actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Phas have molecular weights 2โ€“3ร— larger than ahas, limiting penetration to superficial layers. combined humectant and antioxidant properties make them uniquely well-tolerated while providing meaningful exfoliation.

Last Verified: Cosing database,green & yu (2003) pha review,cir safety assessment

Primary Sources: 2026-03-12

Glycerin

Common Name(s): Glycerol,glycerine,1,2,3-propanetriol

CAS Number: 56-81-5

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“30% (typical: 3โ€“10%)

SOURCING & ETHICS

Vegan Status: Yes โ€“ plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes โ€“ when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

Lysolecithin

Common Name(s): Liposome/lysolecithin,phospholipid delivery vehicle,encapsulated active carrier

CAS Number: N/a

DESCRIPTION

What It Does: Encapsulates water-soluble and lipid-soluble actives in separate aqueous/lipid compartments for controlled release, enhances sc penetration of encapsulated actives through lipid bilayer-sc fusion, and provides biomimetic skin conditioning from the phospholipid structure identical to skin cell membranes.

Why It's Used: Liposomal encapsulation solves the delivery paradox of water-soluble actives in lipid-rich sc: encapsulation in phospholipid bilayers provides simultaneous aqueous (active protection) and lipid (sc compatibility) character enabling sc penetration of otherwise sc-impermeable actives.

How It Works: Phospholipid bilayer vesicles (liposomes) form spontaneously from hydrated phospholipids above their phase transition temperature. at the sc surface, liposome membranes undergo fusion with sc lipid bilayers releasing encapsulated contents into the sc. lysolecithin (single-chain phospholipid) provides surfactant-like sc penetration enhancement through lamellar lipid disruption at sub-cmc concentrations.

Typically Found In: Active delivery systems,premium skin care

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ emollient

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%โ€“5%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 1/5 โ€“ low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Liposome size controls sc penetration: small unilamellar vesicles (suv, 20โ€“100 nm) penetrate follicular route; large multilamellar vesicles (mlv, >500 nm) remain at skin surface for controlled topical release. size selection determines the delivery depth and active release profile.

Last Verified: Cosing database,liposome phospholipid active delivery review

Primary Sources: 2026-03-12