
Highlights
WHAT IS IT?
Acne serum with 14 ingredients
FEATURES
Improves appearance of breakouts in 3 days, 24-hour hydration, resurfaces skin, improves uneven skin tone
BEST FOR
Breakout-prone, sensitive skin
CHECKS
Fragrance-free, paraben-free, won't clog pores
Who Is It For?
Not Specified Likely Suitable For Adults With Acne-prone SkinWhat Does It Help With?
Acne Uneven Skin Tone BreakoutsBudget
AffordableHow To Use
Which routine should it be used in?
Instructions:
Key Information
What Cetaphil Says
Product Description:
This milky-gel serum with 0.5% salicylic acid improves the appearance of breakouts in just 3 days. With 24-hour hydration, it is formulated with soothing succinic acid to resurface skin and improve the appearance of uneven skin tone.
About the Brand:
Ingredients Overview
Ingredients List
Water, Glycerin, Coco-Caprylate/Caprate, Gluconolactone, Propanediol, Sodium Hydroxide, Succinic Acid, Panthenol, Niacinamide, Lysolecithin, Sclerotium Gum, Zinc Gluconate, Pullulan, Xanthan Gum, Pantolactone, Citric Acid, Silica
Key Ingredients
Salicylic Acid 0.5%, Succinic Acid
Ingredients Details
Coco Caprylate/caprate
Common Name(s): Coco caprylate/caprate
DESCRIPTION
What It Does: Smooths and softens skin by filling intercorneocyte spaces, reducing friction, and providing a pleasant aesthetic skin feel in formulations.
Why It's Used: Synthetic esters provide tailored aesthetic properties โ spreadability, skin feel, volatility, refractive index โ that natural oils alone cannot consistently deliver.
How It Works: The ester molecule fills microscopic surface irregularities between corneocytes, reducing coefficient of friction, reflecting light uniformly, and providing a lubrication layer that protects the skin surface.
Typically Found In: Moisturizers,sunscreens,color cosmetics,body lotions,lip products
TECHNICAL DETAILS
Primary Category: Synthetic emollients
Secondary Functions: Emollient
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ20%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced ester emollient; no animal components.
SKIN COMPATIBILITY
Irritancy Rating: 1
Comedogenicity Rating: 1
Sensitivity Concerns: Low sensitization potential at recommended use concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.
Works Well With: Silicones,uv filters,other emollients
Avoid Combining With: Strongly alkaline conditions (risk of saponification of ester-type emollients)
SCIENTIFIC NOTE
The spreading coefficient of an emollient is governed by its surface tension, viscosity, and polarity. esters with branched alkyl chains (e.g., isopropyl, isostearyl) spread rapidly and leave a non-tacky film; linear long-chain esters provide more substantive moisturization. hlb value determines the preferred formulation system (w/o vs o/w emulsions).
Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature
Primary Sources: 2025-01-15
Gluconolactone
Common Name(s): D-gluconolactone,delta-gluconolactone
CAS Number: 90-80-2
DESCRIPTION
What It Does: Provides the gentlest chemical exfoliation with simultaneous antioxidant, moisture retention, and barrier support.
Why It's Used: Preferred exfoliant for rosacea, eczema, sensitive skin, and post-procedure recovery where standard ahas cause unacceptable irritation.
How It Works: Hydrolyzes slowly on skin surface to gluconic acid providing gentle exfoliation. multiple hydroxyl groups enable water binding (humectant) and metal chelation (antioxidant).
Typically Found In: Sensitive skin exfoliants,rosacea treatments,eczema care,post-procedure recovery
TECHNICAL DETAILS
Primary Category: Active ingredient โ polyhydroxy acid (pha)
Secondary Functions: Gentle exfoliation,antioxidant,humectant
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 5%โ15%
SOURCING & ETHICS
Vegan Status: Yes โ fermentation or synthetic
Halal Status: Yes
Source Notes: Fermentation-derived from glucose or synthetic. among the safest chemical exfoliants available.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: No photosensitization; no stinging; suitable for very sensitive skin.
Safe for Sensitive Skin: Yes โ ideal for sensitive, reactive, rosacea, and eczema-prone skin; no photosensitization
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. no photosensitization. ewg score: 1.
Works Well With: Ceramides,niacinamide,hyaluronic acid,soothing actives
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Phas have molecular weights 2โ3ร larger than ahas, limiting penetration to superficial layers. combined humectant and antioxidant properties make them uniquely well-tolerated while providing meaningful exfoliation.
Last Verified: Cosing database,green & yu (2003) pha review,cir safety assessment
Primary Sources: 2026-03-12
Glycerin
Common Name(s): Glycerol,glycerine,1,2,3-propanetriol
CAS Number: 56-81-5
DESCRIPTION
What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.
Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.
How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.
Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners
TECHNICAL DETAILS
Primary Category: Humectant
Secondary Functions: Skin barrier support,emollient,solvent
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1%โ30% (typical: 3โ10%)
SOURCING & ETHICS
Vegan Status: Yes โ plant-derived (coconut, soy, palm) or synthetic
Halal Status: Yes โ when plant-derived or synthetic; verify source with supplier
Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low; non-irritating at all standard concentrations
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).
Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas
Avoid Combining With: No known incompatibilities at standard concentrations
SCIENTIFIC NOTE
Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.
Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder
Primary Sources: 2026-03-12
Lysolecithin
Common Name(s): Liposome/lysolecithin,phospholipid delivery vehicle,encapsulated active carrier
CAS Number: N/a
DESCRIPTION
What It Does: Encapsulates water-soluble and lipid-soluble actives in separate aqueous/lipid compartments for controlled release, enhances sc penetration of encapsulated actives through lipid bilayer-sc fusion, and provides biomimetic skin conditioning from the phospholipid structure identical to skin cell membranes.
Why It's Used: Liposomal encapsulation solves the delivery paradox of water-soluble actives in lipid-rich sc: encapsulation in phospholipid bilayers provides simultaneous aqueous (active protection) and lipid (sc compatibility) character enabling sc penetration of otherwise sc-impermeable actives.
How It Works: Phospholipid bilayer vesicles (liposomes) form spontaneously from hydrated phospholipids above their phase transition temperature. at the sc surface, liposome membranes undergo fusion with sc lipid bilayers releasing encapsulated contents into the sc. lysolecithin (single-chain phospholipid) provides surfactant-like sc penetration enhancement through lamellar lipid disruption at sub-cmc concentrations.
Typically Found In: Active delivery systems,premium skin care
TECHNICAL DETAILS
Primary Category: Functional ingredient โ emollient
Secondary Functions: Barrier sealing,softening
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ5%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Yes
Source Notes: Plant-derived, synthetic or animal-derived. verify source.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 1/5 โ low; formulation-dependent
Sensitivity Concerns: Non-irritating.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Humectants,ceramides,actives as carrier
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Liposome size controls sc penetration: small unilamellar vesicles (suv, 20โ100 nm) penetrate follicular route; large multilamellar vesicles (mlv, >500 nm) remain at skin surface for controlled topical release. size selection determines the delivery depth and active release profile.
Last Verified: Cosing database,liposome phospholipid active delivery review
Primary Sources: 2026-03-12