
Highlights
WHAT IS IT?
Face firming serum with multiple active ingredients
FEATURES
Anti-wrinkle serum, smooth skin and visibly reduce the length, width and depth of wrinkles.
BEST FOR
Not specifically stated, but likely suitable for aging skin
CHECKS
Free from gluten, fish, milk, corn, phthalates, sulfates, parabens, oil, talc, and mineral oil
Who Is It For?
Adults (default Above 18) Both Women And MenWhat Does It Help With?
Wrinkles Enlarged Pores Skin Texture RadianceBudget
PremiumHow To Use
Which routine should it be used in?
Instructions:
Key Information
What Perricone MD Says
Product Description:
A powerhouse anti-wrinkle serum that includes the highest potency of Perricone MD's signature sciences. This intense wrinkle serum features alpha lipoic acid to help smooth skin and visibly reduce the length, width and depth of wrinkles.
About the Brand:
Ingredients Overview
Ingredients List
Water/Aqua/Eau, Dimethyl MEA, Thioctic Acid, Isopropyl Palmitate, Cetearyl Alcohol, Tyrosine, Glycolic Acid, Dimethyl Isosorbide, Propanediol, Glyceryl Stearate, PEG-100 Stearate, Urea, Phosphatidylcholine, Xanthan Gum, Magnesium Aspartate, Zinc Gluconate, Acetyl Tyrosine, Pyridoxine HCL, Copper Gluconate, Sodium Hyaluronate, BHT, Disodium EDTA, Ceteareth-20, Ammonium Acryloyldimethyltaurate/VP Copolymer, Dimethicone, Caprylyl Glycol, Zinc Sulfate, Phenoxyethanol, Sorbic Acid, Fragrance/Parfum, Citral, Citronellol, Geraniol, Limonene, Linalool
Key Ingredients
Alpha Lipoic Acid (ALA), DMAE, Hyaluronic Acid (HA)
Ingredients Details
Cetearyl Alcohol
Common Name(s): Cetostearyl alcohol,c16-18 fatty alcohol
CAS Number: 8005-44-5
DESCRIPTION
What It Does: Provides fatty alcohol emulsification and thickening for stable, well-textured emulsions.
Why It's Used: The most widely used fatty alcohol in cosmetics โ provides emulsification, thickening, and emolliency simultaneously from a single ingredient with excellent safety profile.
How It Works: Forms bilayer lamellar structures in water with emulsifiers creating a viscous structured network that thickens and stabilizes emulsions. fatty alcohol emolliency provides direct skin conditioning. bilayer formation reduces inter-droplet coalescence in emulsions.
Typically Found In: Creams,lotions,conditioners โ virtually all emulsion products
TECHNICAL DETAILS
Primary Category: Functional ingredient โ fatty alcohol emulsifier/thickener
Secondary Functions: Barrier sealing,softening
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1%โ25%
SOURCING & ETHICS
Vegan Status: Yes โ from vegetable or coconut/palm fatty acids
Halal Status: Yes
Source Notes: Plant-derived, synthetic or animal-derived. verify source.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 1/5 โ low; formulation-dependent
Sensitivity Concerns: Non-irritating.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Humectants,ceramides,actives as carrier
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Cetearyl alcohol's ability to form lamellar liquid crystal structures ('krafft phases') with water and co-emulsifiers provides not only emulsion stability but also enhanced skin penetration via the lamellar skin barrier pathway. these crystalline structures can act as a reservoir for active ingredients, slowly releasing them as the lamellar structure melts on skin contact.
Last Verified: Cosing database,cir safety assessment
Primary Sources: 2026-03-12
Dimethyl Isosorbide
Common Name(s): Dmi,isosorbide dimethyl ether,arlasolve dmi
CAS Number: 5306-85-4
DESCRIPTION
What It Does: Provides biocompatible penetration enhancement for improved active ingredient delivery.
Why It's Used: Biocompatible penetration enhancer from renewable sorbitol โ dmi provides penetration enhancement without the toxicity of oleic acid or conventional chemical penetration enhancers.
How It Works: Cyclic ether from sorbitol is biocompatible and biodegradable. disrupts stratum corneum lipid packing via ether oxygen hydrogen bonding. solubilises challenging actives (retinoids, salicylic acid, ahas). enhances penetration 2โ5ร vs equivalent concentrations without dmi.
Typically Found In: Active delivery formulas,penetration-enhanced products,retinoid vehicles
TECHNICAL DETAILS
Primary Category: Functional ingredient โ penetration-enhancing solvent
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1%โ20%
SOURCING & ETHICS
Vegan Status: Yes โ from sorbitol (corn or wheat derived)
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Dmi's penetration enhancement mechanism differs from oleic acid's lipid disruption: dmi hydrogen bonds to stratum corneum proteins and lipids, temporarily creating more permeable protein-lipid domains without the membrane-fluidisation that causes oleic acid's irritation. this protein-hydrogen-bonding mechanism provides penetration enhancement from a different, gentler pathway.
Last Verified: Cosing database,croda arlasolve dmi technical data,cir safety assessment
Primary Sources: 2026-03-12
Dimethyl Mea
Common Name(s): Dmae,dimethylaminoethanol,membrane stabiliser anti-aging
CAS Number: N/a
DESCRIPTION
What It Does: Provides immediate skin firmness from the topical amine's interaction with skin surface proteins, reduces age-related lipofuscin accumulation in cell membranes through acetylcholine pathway enhancement, and conditions skin with mild surfactant activity.
Why It's Used: Dmae's dual immediate-effect (surface protein tightening) and long-term mechanism (membrane lipofuscin reduction) enables both instant and cumulative anti-aging claim support from one ingredient.
How It Works: Dmae as a membrane phospholipid precursor incorporates into cell membranes as dimethylethanolamine phospholipid, improving membrane fluidity and reducing cross-linked lipofuscin accumulation. at the skin surface, dmae's cationic amine group interacts with skin surface carboxylate groups creating mild surface contraction providing immediate firmness perception.
Typically Found In: Anti-aging firming,membrane health
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ3%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Dmae penetration studies show significant transdermal absorption (significantly more than most cosmetic actives) โ the cholinergic activity may have systemic implications at high concentrations. use at standard cosmetic concentrations (0.5โ3%) is considered safe.
Last Verified: Cosing database,dmae membrane stabiliser anti-aging review
Primary Sources: 2026-03-12
Glyceryl Stearate
Common Name(s): Glycerol monostearate,gms,glycerin monostearate
CAS Number: 31566-31-1
DESCRIPTION
What It Does: Provides o/w emulsification with emolliency and skin feel improvement from a natural glycerol ester.
Why It's Used: Standard cosmetic monoglyceride emulsifier โ widely used for o/w cream formation with clean, natural-origin credentials and good sensory profile.
How It Works: Monoglyceride structure (one fatty acid + glycerol) provides amphiphilic hlb ~3-4 for o/w emulsification when combined with higher hlb co-emulsifiers. forms alpha-gel lamellar structure with water for emulsion stabilization. direct skin conditioning via fatty acid film.
Typically Found In: Creams,lotions,moisturizers โ standard in o/w emulsions
TECHNICAL DETAILS
Primary Category: Functional ingredient โ monoglyceride emulsifier
Secondary Functions: Barrier sealing,softening
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1%โ10%
SOURCING & ETHICS
Vegan Status: Yes โ from vegetable glycerol and stearic acid
Halal Status: Yes
Source Notes: Plant-derived, synthetic or animal-derived. verify source.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 1/5 โ low; formulation-dependent
Sensitivity Concerns: Non-irritating.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Humectants,ceramides,actives as carrier
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Glyceryl stearate's alpha-gel lamellar phase formation (distinguishable by x-ray crystallography from beta crystalline phase) provides superior emulsion stability compared to its beta crystalline form. the alpha-gel phase creates a viscoelastic network that resists droplet coalescence โ the fundamental mechanism behind gms's long use as a reliable primary emulsifier.
Last Verified: Cosing database,cir safety assessment
Primary Sources: 2026-03-12