High Potency Classics Face Firming Serum

Perricone MD

High Potency Classics Face Firming Serum

High Potency Classics Face Firming Serum

Perricone MD

high-potency-classics-face-firming-serum

Serum

9643623186725

Morning or Evening?

Morning
Evening
Both

How often will you use this product?

Everyday
Every other day
Every 3 days
Every 4 days
Every 5 days
Every 6 days
Once a week
Twice a week
On specific days
As needed
On rotation

Notes

Add to Routine
Compare with Similar

Compatibility Score

0%

Microbiome
Ingredients
Biological
Environment
Lifestyle

How It Fits Into Your Skincare Routine

Login to see compatibility score and learn how this works with your skin.

Highlights

WHAT IS IT?

Face firming serum with multiple active ingredients

FEATURES

Anti-wrinkle serum, smooth skin and visibly reduce the length, width and depth of wrinkles.

BEST FOR

Not specifically stated, but likely suitable for aging skin

CHECKS

Free from gluten, fish, milk, corn, phthalates, sulfates, parabens, oil, talc, and mineral oil

Who Is It For?

Adults (default Above 18) Both Women And Men

What Does It Help With?

Wrinkles Enlarged Pores Skin Texture Radiance

Budget

Premium

How To Use

Which routine should it be used in?

Morning
Evening
 
Cleanse
Tone
Eyecare
Serum
Moisturize
Suncare
 

Instructions:

After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.

Key Information

Vegan
Cruelty-free
Sensitive-safe
Non-comedogenic
Hypoallergenic
Microbiome-safe
Preservative-free
Eco-friendly
Pregnancy-safe
Oil-free

What Perricone MD Says

Product Description:

A powerhouse anti-wrinkle serum that includes the highest potency of Perricone MD's signature sciences. This intense wrinkle serum features alpha lipoic acid to help smooth skin and visibly reduce the length, width and depth of wrinkles.

About the Brand:

Founded by Dr. Nicholas Perricone, Perricone MD is a pioneer in the science of aging. This brand takes a holistic approach to skincare, combining cutting-edge ingredients with a focus on nutrition and lifestyle. Experience transformative results with products that address not just the signs of aging, but its underlying causes.

Ingredients Overview

Ingredients List

Water/Aqua/Eau, Dimethyl MEA, Thioctic Acid, Isopropyl Palmitate, Cetearyl Alcohol, Tyrosine, Glycolic Acid, Dimethyl Isosorbide, Propanediol, Glyceryl Stearate, PEG-100 Stearate, Urea, Phosphatidylcholine, Xanthan Gum, Magnesium Aspartate, Zinc Gluconate, Acetyl Tyrosine, Pyridoxine HCL, Copper Gluconate, Sodium Hyaluronate, BHT, Disodium EDTA, Ceteareth-20, Ammonium Acryloyldimethyltaurate/VP Copolymer, Dimethicone, Caprylyl Glycol, Zinc Sulfate, Phenoxyethanol, Sorbic Acid, Fragrance/Parfum, Citral, Citronellol, Geraniol, Limonene, Linalool

Key Ingredients

Alpha Lipoic Acid (ALA), DMAE, Hyaluronic Acid (HA)

Ingredients Details

Cetearyl Alcohol

Common Name(s): Cetostearyl alcohol,c16-18 fatty alcohol

CAS Number: 8005-44-5

DESCRIPTION

What It Does: Provides fatty alcohol emulsification and thickening for stable, well-textured emulsions.

Why It's Used: The most widely used fatty alcohol in cosmetics โ€“ provides emulsification, thickening, and emolliency simultaneously from a single ingredient with excellent safety profile.

How It Works: Forms bilayer lamellar structures in water with emulsifiers creating a viscous structured network that thickens and stabilizes emulsions. fatty alcohol emolliency provides direct skin conditioning. bilayer formation reduces inter-droplet coalescence in emulsions.

Typically Found In: Creams,lotions,conditioners โ€“ virtually all emulsion products

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ fatty alcohol emulsifier/thickener

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“25%

SOURCING & ETHICS

Vegan Status: Yes โ€“ from vegetable or coconut/palm fatty acids

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 1/5 โ€“ low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Cetearyl alcohol's ability to form lamellar liquid crystal structures ('krafft phases') with water and co-emulsifiers provides not only emulsion stability but also enhanced skin penetration via the lamellar skin barrier pathway. these crystalline structures can act as a reservoir for active ingredients, slowly releasing them as the lamellar structure melts on skin contact.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

Dimethyl Isosorbide

Common Name(s): Dmi,isosorbide dimethyl ether,arlasolve dmi

CAS Number: 5306-85-4

DESCRIPTION

What It Does: Provides biocompatible penetration enhancement for improved active ingredient delivery.

Why It's Used: Biocompatible penetration enhancer from renewable sorbitol โ€” dmi provides penetration enhancement without the toxicity of oleic acid or conventional chemical penetration enhancers.

How It Works: Cyclic ether from sorbitol is biocompatible and biodegradable. disrupts stratum corneum lipid packing via ether oxygen hydrogen bonding. solubilises challenging actives (retinoids, salicylic acid, ahas). enhances penetration 2โ€“5ร— vs equivalent concentrations without dmi.

Typically Found In: Active delivery formulas,penetration-enhanced products,retinoid vehicles

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ penetration-enhancing solvent

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“20%

SOURCING & ETHICS

Vegan Status: Yes โ€“ from sorbitol (corn or wheat derived)

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ€“2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Dmi's penetration enhancement mechanism differs from oleic acid's lipid disruption: dmi hydrogen bonds to stratum corneum proteins and lipids, temporarily creating more permeable protein-lipid domains without the membrane-fluidisation that causes oleic acid's irritation. this protein-hydrogen-bonding mechanism provides penetration enhancement from a different, gentler pathway.

Last Verified: Cosing database,croda arlasolve dmi technical data,cir safety assessment

Primary Sources: 2026-03-12

Dimethyl Mea

Common Name(s): Dmae,dimethylaminoethanol,membrane stabiliser anti-aging

CAS Number: N/a

DESCRIPTION

What It Does: Provides immediate skin firmness from the topical amine's interaction with skin surface proteins, reduces age-related lipofuscin accumulation in cell membranes through acetylcholine pathway enhancement, and conditions skin with mild surfactant activity.

Why It's Used: Dmae's dual immediate-effect (surface protein tightening) and long-term mechanism (membrane lipofuscin reduction) enables both instant and cumulative anti-aging claim support from one ingredient.

How It Works: Dmae as a membrane phospholipid precursor incorporates into cell membranes as dimethylethanolamine phospholipid, improving membrane fluidity and reducing cross-linked lipofuscin accumulation. at the skin surface, dmae's cationic amine group interacts with skin surface carboxylate groups creating mild surface contraction providing immediate firmness perception.

Typically Found In: Anti-aging firming,membrane health

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%โ€“3%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Dmae penetration studies show significant transdermal absorption (significantly more than most cosmetic actives) โ€” the cholinergic activity may have systemic implications at high concentrations. use at standard cosmetic concentrations (0.5โ€“3%) is considered safe.

Last Verified: Cosing database,dmae membrane stabiliser anti-aging review

Primary Sources: 2026-03-12

Glyceryl Stearate

Common Name(s): Glycerol monostearate,gms,glycerin monostearate

CAS Number: 31566-31-1

DESCRIPTION

What It Does: Provides o/w emulsification with emolliency and skin feel improvement from a natural glycerol ester.

Why It's Used: Standard cosmetic monoglyceride emulsifier โ€“ widely used for o/w cream formation with clean, natural-origin credentials and good sensory profile.

How It Works: Monoglyceride structure (one fatty acid + glycerol) provides amphiphilic hlb ~3-4 for o/w emulsification when combined with higher hlb co-emulsifiers. forms alpha-gel lamellar structure with water for emulsion stabilization. direct skin conditioning via fatty acid film.

Typically Found In: Creams,lotions,moisturizers โ€“ standard in o/w emulsions

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ monoglyceride emulsifier

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“10%

SOURCING & ETHICS

Vegan Status: Yes โ€“ from vegetable glycerol and stearic acid

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 1/5 โ€“ low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Glyceryl stearate's alpha-gel lamellar phase formation (distinguishable by x-ray crystallography from beta crystalline phase) provides superior emulsion stability compared to its beta crystalline form. the alpha-gel phase creates a viscoelastic network that resists droplet coalescence โ€“ the fundamental mechanism behind gms's long use as a reliable primary emulsifier.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12