Hypoallergenic Clean Correction Smoothing Restorative Serum

Perricone MD

Hypoallergenic Clean Correction Smoothing Restorative Serum

Hypoallergenic Clean Correction Smoothing Restorative Serum

Perricone MD

hypoallergenic-clean-correction-smoothing-restorative-serum

Serum

9643616731429

Morning or Evening?

Morning
Evening
Both

How often will you use this product?

Everyday
Every other day
Every 3 days
Every 4 days
Every 5 days
Every 6 days
Once a week
Twice a week
On specific days
As needed
On rotation

Notes

Add to Routine
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Compatibility Score

0%

Microbiome
Ingredients
Biological
Environment
Lifestyle

How It Fits Into Your Skincare Routine

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Highlights

WHAT IS IT?

Serum with multiple ingredients

FEATURES

Vegan, non-comedogenic, dermatologist-tested, free of 26 known allergens, fragrance-free, gluten-free, sulfate-free, silicone-free, paraben-free

BEST FOR

Sensitive skin

CHECKS

Does not contain fragrance, gluten, sulfates, silicones, parabens, formaldehyde, butylene- and propylene-glycol, peg, phthalates, bha and bht

Who Is It For?

Adults Both Women And Men

What Does It Help With?

Fine Lines Wrinkles Uneven Tone Uneven Texture Dullness Irritated Skin

Budget

Premium

How To Use

Which routine should it be used in?

Morning
Evening
 
Cleanse
Tone
Eyecare
Serum
Moisturize
Suncare
 

Instructions:

After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.

Key Information

Vegan
Cruelty-free
Sensitive-safe
Non-comedogenic
Hypoallergenic
Microbiome-safe
Preservative-free
Eco-friendly
Pregnancy-safe
Oil-free

What Perricone MD Says

Product Description:

This gentle yet effective serum reduces the look of fine lines, wrinkles, uneven tone and uneven texture for a smoother, healthier and more radiant appearance. Lightweight and fast-absorbing, this ultra-lightweight serum soothes and comforts sensitive skin.

About the Brand:

Founded by Dr. Nicholas Perricone, Perricone MD is a pioneer in the science of aging. This brand takes a holistic approach to skincare, combining cutting-edge ingredients with a focus on nutrition and lifestyle. Experience transformative results with products that address not just the signs of aging, but its underlying causes.

Ingredients Overview

Ingredients List

Water/Aqua/Eau, Isononyl Isononanoate, Niacinamide, Polyglyceryl-4 Caprate, Propanediol, Glyceryl Stearate SE, Beta Vulgaris (Beet) Root Extract, Bakuchiol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Brassica Campestris (Rapeseed) Seed Oil, Caprylyl Glycol, 1,2-Hexanediol, Phosphatidylcholine, Glycerin, Panthenol, Lactobacillus/Soybean Ferment Extract, Lycium Chinense Stem Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Polyglyceryl-3 Diisostearate, Cucumis Sativus (Cucumber) Fruit Extract, Potassium Stearate, Citric Acid, Sorbitan Isostearate, Ocimum Sanctum Leaf Extract, Phaseolus Angularis Seed Extract, Lactic Acid, Lysine, Mannose, Sodium Mannose Phosphate, Althaea Officinalis Root Extract, Oryza Sativa (Rice) Bran Water, Xanthan Gum, Copper Sulfate, Proline, Pentylene Glycol, Tocopherol, Ascorbyl Palmitate

Key Ingredients

Bakuchiol, Niacinamide, Holy Basil

Ingredients Details

Bakuchiol

Common Name(s): Bakuchiol,(s)-bakuchiol

CAS Number: 10309-37-2

DESCRIPTION

What It Does: Provides retinol-equivalent anti-aging gene expression from a natural plant compound without retinol's limitations.

Why It's Used: The natural retinol alternative โ€” the first plant compound with rct evidence for equivalent anti-aging results to retinol with better safety and photostability.

How It Works: Bakuchiol activates rar beta and retinoid x receptors via allosteric binding mechanism. upregulates type i, iii, and iv collagen synthesis genes. downregulates mmp-1 and mmp-9. antioxidant via phenol radical scavenging. photostable โ€” stable to uv exposure unlike retinol.

Typically Found In: Natural anti-aging serums,pregnancy-safe retinol alternative,photostable anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ natural retinol alternative

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%โ€“2%

SOURCING & ETHICS

Vegan Status: Yes โ€“ from psoralea corylifolia seeds

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

The dhaliwal et al. (2019, british journal of dermatology) split-face rct directly compared 0.5% bakuchiol vs 0.5% retinol twice daily for 12 weeks โ€” both groups showed equivalent reduction in fine lines and wrinkles, but bakuchiol showed significantly less scaling, stinging, and burning. this is the strongest evidence that bakuchiol provides retinol-equivalent anti-aging with better tolerability.

Last Verified: Cosing database,dhaliwal et al. bakuchiol vs retinol rct

Primary Sources: 2026-03-12

Brassica Campestris (rapeseed) Seed Oil

Common Name(s): Brassica campestris (rapeseed) seed oil,botanical oil,phytochemical active

CAS Number: N/a

DESCRIPTION

What It Does: Provides antioxidant protection from reactive oxygen species, reduces inflammatory cytokine production in skin, and conditions skin surface through the plant's secondary metabolite complex.

Why It's Used: Chosen for its natural origin narrative, traditional use heritage, and multi-functional phytochemical profile that supports several concurrent skin care claims from one ingredient.

How It Works: Polyphenols, terpenoids, and alkaloids in the oil scavenge ros via hydrogen atom transfer, inhibit nf-kb or cox-2 inflammatory pathways, and interact with skin surface proteins for conditioning.

Typically Found In: Botanical skin care,natural products

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%โ€“10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Plant secondary metabolites evolved as uv photoprotectants and antimicrobial agents โ€” mechanisms that directly translate to cosmetic antioxidant and anti-inflammatory activity in human skin.

Last Verified: Cosing database,brassica campestris (rapeseed) seed botanical review

Primary Sources: 2026-03-12

Glyceryl Stearate Se

Common Name(s): Glyceryl monostearate se,self-emulsifying glyceryl stearate

DESCRIPTION

What It Does: Provides self-emulsifying o/w emulsification with less co-emulsifier requirement.

Why It's Used: Simplified emulsification for formulations where self-emulsification reduces complexity vs standard gms requiring hlb-matched co-emulsifier blends.

How It Works: Small amount of embedded sodium/potassium stearate soap provides in-situ hlb modification enabling self-emulsification without requiring precisely hlb-matched co-emulsifier. forms stable o/w emulsions with water alone under high-shear mixing.

Typically Found In: Simple cream formulations,single-emulsifier systems

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ self-emulsifying monoglyceride

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“10%

SOURCING & ETHICS

Vegan Status: Yes โ€“ from vegetable glycerol and stearic acid

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 1/5 โ€“ low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Glyceryl stearate se's built-in self-emulsification arises from the small percentage (~2-5%) of potassium stearate soap co-crystallized with the monoglyceride. this soap provides the high-hlb co-emulsifier 'partner' needed for stable o/w emulsification without requiring the formulator to select and add a separate high-hlb emulsifier โ€“ an elegant simplification of classic emulsifier hlb matching theory.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

Hydroxyethyl Acrylate/sodium Acryloyldimethyl Taurate Copolymer

Common Name(s): Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer

DESCRIPTION

What It Does: Provides antioxidant protection, soothing anti-inflammatory effects, and skin-conditioning benefits through plant-derived polyphenols and phytochemicals.

Why It's Used: Plant extracts concentrate bioactive phytochemicals evolved for environmental protection โ€” uv, microbial, and oxidative stressors โ€” that translate to skin benefits.

How It Works: Polyphenols (flavonoids, phenolic acids) inhibit nf-ฮบb-mediated inflammatory signaling, scavenge reactive oxygen species through electron donation, and chelate pro-oxidant metal ions to reduce oxidative skin damage.

Typically Found In: Lotions,creams,serums,masks

TECHNICAL DETAILS

Primary Category: Minerals

Secondary Functions: Skin-conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1โ€“10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Mineral-derived ingredient; no biological origin.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 0

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Plant extracts,peptides,vitamins

Avoid Combining With: Strong chelating agents (reduce mineral availability)

SCIENTIFIC NOTE

Plant secondary metabolites (flavonoids, terpenes, phenolic acids) are biosynthesized as defense compounds against uv, herbivores, and pathogens. their anti-inflammatory activity typically derives from competitive inhibition of cox-2 and 5-lox enzymes (ic50 1โ€“50 ยตm), while antioxidant activity involves single electron transfer (set) and hydrogen atom transfer (hat) mechanisms with structure-dependent rate constants.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature

Primary Sources: 2025-01-15