Inlief Hydrating Facewash 100 gm

DESCRIPTION

What It Does: Provides punicalagin-based exceptional antioxidant activity with anti-inflammatory and skin regeneration benefits.

Why It's Used: Highest-orac common fruit extract – punicalagins provide unmatched antioxidant activity alongside oestrogenic urolithins for anti-aging and barrier support.

How It Works: Punicalagins a and b (2x the antioxidant power of red wine) provide orac value ~10,000 μmol te/g. metabolized to urolithins by skin microbiome – urolithin a activates mitophagy for cellular anti-aging. ellagic acid inhibits tyrosinase for brightening. mild estrogenic activity via urolithin phytoestrogens.

Typically Found In: Premium antioxidant products,brightening formulas,anti-aging serums

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Punicalagin orac,urolithin mitophagy

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes – from punica granatum fruit

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pomegranate punicalagin's conversion to urolithin a by skin microbiome represents a remarkable prebiotic-probiotic relationship: the skin's resident bacteria metabolize the polyphenol precursor to create the bioactive urolithin that activates mitophagy (cellular mitochondrial quality control). this microbiome-dependent bioactivation means the same punicalagin extract has different anti-aging potency across individuals depending on their microbiome composition.

Last Verified: Cosing database,seeram et al. pomegranate punicalagin review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Deeply hydrates by binding water in the viable epidermis (not just the sc surface), stimulates keratinocyte proliferation for wound healing and barrier repair, and coats hair strands for conditioning and shine.

Why It's Used: Panthenol penetrates far deeper than glycerin due to its smaller size — reaching the viable epidermis where it converts to pantothenic acid (coa precursor) for direct metabolic support of skin cell function.

How It Works: D-panthenol is oxidised to pantothenic acid by skin alcoholic dehydrogenase after sc penetration → incorporated into coenzyme a (coa) → acetyl-coa for fatty acid synthesis supporting ceramide production. the polyol oh groups provide direct humectant water binding during transit.

Typically Found In: Healing skin care,conditioning,hair products

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Panthenol's unique dual mechanism — provitamin metabolic activity (via coa) and direct humectant function (via oh groups) — provides both immediate surface moisture and deeper metabolic skin support from a single vitamin ingredient.

Last Verified: Cosing database,d-panthenol vitamin b5 humectant wound healing review

Primary Sources: 2026-03-12