Kerastase Chronologiste Shampoo For Anti-Aging, With Hyaluronic Acid & Vitamin E

DESCRIPTION

What It Does: Delivers targeted skin-conditioning or bioactive benefits through a specific mechanism of action suited to the formulation's intended purpose.

Why It's Used: Specialty actives address specific skin concerns through targeted molecular mechanisms, providing efficacy beyond what base formulation ingredients alone can achieve.

How It Works: The bioactive compound interacts with specific molecular targets in skin cells or the extracellular matrix — enzymes, receptors, structural proteins, or signaling molecules — triggering beneficial biological responses.

Typically Found In: Serums,treatments,moisturizers,specialty products

TECHNICAL DETAILS

Primary Category: Specialty actives

Secondary Functions: Skin-conditioning,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Specialty active ingredient; check individual sourcing for vegan status.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 0

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Niacinamide,hyaluronic acid,vitamin c,peptides

Avoid Combining With: Incompatible with oxidizing agents; check ph stability

SCIENTIFIC NOTE

Specialty actives typically work through enzyme inhibition (e.g., tyrosinase inhibition for brightening, mmp inhibition for anti-aging), receptor activation (e.g., retinoid receptors, ppar-γ for barrier genes), or transcription factor modulation (e.g., nrf2 for antioxidant gene upregulation). structure-activity relationships determine potency and selectivity.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Provides amino group-mediated preferential adsorption to damaged hair for targeted conditioning.

Why It's Used: Premium hair conditioning silicone – amino groups provide substantive adsorption to hair far exceeding pdms, with automatic targeting to the most damaged areas requiring conditioning.

How It Works: Amino (nh2) groups on silicone chain provide cationic character at normal ph, electrostatic adsorption to anionic hair surface. higher charge density at damaged sites increases adsorption where conditioning is most needed. si-o-si backbone provides permanent conditioning film with heat protection.

Typically Found In: Intensive conditioners,anti-frizz products,damage repair conditioners

TECHNICAL DETAILS

Primary Category: Functional ingredient – amino-functional silicone

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Amodimethicone's amino group-driven substantivity to damaged hair is dramatically greater than non-functionalized pdms. studies show amodimethicone deposits 50-200× more mass on bleach-damaged hair vs virgin hair, providing an automatic 'damage detection' conditioning system that directs the most conditioning to the hair areas that need it most.

Last Verified: Cosing database,robbins hair science,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers targeted skin-conditioning or bioactive benefits through a specific mechanism of action suited to the formulation's intended purpose.

Why It's Used: Specialty actives address specific skin concerns through targeted molecular mechanisms, providing efficacy beyond what base formulation ingredients alone can achieve.

How It Works: The bioactive compound interacts with specific molecular targets in skin cells or the extracellular matrix — enzymes, receptors, structural proteins, or signaling molecules — triggering beneficial biological responses.

Typically Found In: Serums,treatments,moisturizers,specialty products

TECHNICAL DETAILS

Primary Category: Specialty actives

Secondary Functions: Skin-conditioning,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Specialty active ingredient; check individual sourcing for vegan status.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 0

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Niacinamide,hyaluronic acid,vitamin c,peptides

Avoid Combining With: Incompatible with oxidizing agents; check ph stability

SCIENTIFIC NOTE

Specialty actives typically work through enzyme inhibition (e.g., tyrosinase inhibition for brightening, mmp inhibition for anti-aging), receptor activation (e.g., retinoid receptors, ppar-γ for barrier genes), or transcription factor modulation (e.g., nrf2 for antioxidant gene upregulation). structure-activity relationships determine potency and selectivity.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Reduces skin inflammation, soothes irritation, promotes wound healing, and enhances penetration of co-formulated actives.

Why It's Used: Premium natural soothing active with combined anti-inflammatory, wound healing, and penetration-enhancing activity – clinically validated across sensitive, reactive, and irritated skin types.

How It Works: Inhibits nf-kb pathway reducing pro-inflammatory cytokines il-1β, il-6, tnf-α. enhances stratum corneum lipid fluidity increasing penetration of co-delivered actives. antimicrobial against s. aureus and c. albicans. promotes keratinocyte migration for wound healing.

Typically Found In: Sensitive skin products,post-procedure formulations,anti-irritant formulas,wound healing

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Anti-inflammatory,penetration enhancement,antimicrobial

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–1%

SOURCING & ETHICS

Vegan Status: Yes – from candeia tree (vanillosmopsis erythropappa) or synthetic

Halal Status: Yes

Source Notes: Natural (-)-alpha-bisabolol from brazilian candeia tree is more sustainable and potent than chamomile-derived bisabolol. synthetic (±)-bisabolol is racemic with slightly lower anti-inflammatory potency.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Bisabolol's dual function as both an anti-inflammatory and a penetration enhancer is synergistic – by reducing the inflammatory response that increases barrier tightness while simultaneously fluidizing stratum corneum lipids, it provides enhanced delivery of co-formulated actives in the very conditions where delivery is most needed.

Last Verified: Cosing database,piazza et al. bisabolol anti-inflammatory study,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Reduces skin inflammation, soothes irritation, promotes wound healing, and enhances penetration of co-formulated actives.

Why It's Used: Premium natural soothing active with combined anti-inflammatory, wound healing, and penetration-enhancing activity – clinically validated across sensitive, reactive, and irritated skin types.

How It Works: Inhibits nf-kb pathway reducing pro-inflammatory cytokines il-1β, il-6, tnf-α. enhances stratum corneum lipid fluidity increasing penetration of co-delivered actives. antimicrobial against s. aureus and c. albicans. promotes keratinocyte migration for wound healing.

Typically Found In: Sensitive skin products,post-procedure formulations,anti-irritant formulas,wound healing

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Anti-inflammatory,penetration enhancement,antimicrobial

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–1%

SOURCING & ETHICS

Vegan Status: Yes – from candeia tree (vanillosmopsis erythropappa) or synthetic

Halal Status: Yes

Source Notes: Natural (-)-alpha-bisabolol from brazilian candeia tree is more sustainable and potent than chamomile-derived bisabolol. synthetic (±)-bisabolol is racemic with slightly lower anti-inflammatory potency.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Bisabolol's dual function as both an anti-inflammatory and a penetration enhancer is synergistic – by reducing the inflammatory response that increases barrier tightness while simultaneously fluidizing stratum corneum lipids, it provides enhanced delivery of co-formulated actives in the very conditions where delivery is most needed.

Last Verified: Cosing database,piazza et al. bisabolol anti-inflammatory study,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides soft, lasting rose-floral fragrance note.

Why It's Used: Essential rose fragrance monoterpene for lasting smooth floral notes in high-quality perfumery and cosmetic fragrances.

How It Works: Allylic alcohol monoterpene provides fixative property in fragrance blends. good skin substantivity for lasting scent. softer, rounder rose note vs geraniol's fresher character. natural in rose otto at 18-34%.

Typically Found In: Rose perfumes,floral fragrances,luxury skincare

TECHNICAL DETAILS

Primary Category: Fragrance component – monoterpene alcohol

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.001%–1%

SOURCING & ETHICS

Vegan Status: Yes – from rose, geranium, citronella oils

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu cosmetics regulation: declared fragrance allergen. ifra guidelines apply.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Citronellol's r-enantiomer (natural) vs s-enantiomer (synthetic) provide meaningfully different scent character – a remarkable demonstration of chiral scent discrimination by olfactory receptors. the (r) form provides the characteristic rose note while the (s) form has a distinctly different, less pleasant character. this enantiomeric scent difference means that the biological handedness of naturally-sourced vs racemic synthetic citronellol produces perceptibly different fragrance quality.

Last Verified: Cosing database,ifra standards

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides documented cosmetic activity from coco-betaine.

Why It's Used: Coco-betaine delivers formulation value through its specific biological activity and established safety and efficacy.

How It Works: Source: coco-betaine. mechanism: documented in cosmetic literature. safety: cosing-reviewed. standard cosmetic use concentrations.

Typically Found In: Skin care formulations,active products

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Coco-betaine provides cosmetic activity through its characteristic mechanism. at standard concentrations it delivers documented biological activity with an established safety profile from cosmetic science literature and regulatory review.

Last Verified: Cosing database,coco-betaine technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides fresh rose-geranium floral scent with antimicrobial activity.

Why It's Used: The rose fragrance terpene – geraniol defines the fresh, sweet rose-geranium note found in more than 60 essential oils and is essential for recreating natural floral fragrance profiles.

How It Works: Monoterpene alcohol inhibits bacterial membrane integrity for antimicrobial activity. activates trpv1 for anti-nociception. inhibits nf-kb for anti-inflammatory activity. antioxidant via allylic radical scavenging.

Typically Found In: Rose-scented products,floral fragrances,natural cosmetics

TECHNICAL DETAILS

Primary Category: Fragrance component – acyclic monoterpene alcohol

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.001%–1%

SOURCING & ETHICS

Vegan Status: Yes – from rose, geranium, palmarosa oils

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu cosmetics regulation: declared fragrance allergen. ifra guidelines apply.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Geraniol's isomers (geraniol, nerol, citronellol) provide subtly different scent characters despite identical molecular formulae (c10h18o): geraniol provides the sweet, fresh rose note while its z-isomer nerol has a more delicate, neroli-like character. these isomeric scent differences arise from different spatial presentation of the hydroxyl and double bond groups to the olfactory receptor – demonstrating the extraordinary structural sensitivity of olfactory perception.

Last Verified: Cosing database,ifra standards

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Hyaluronic acid draws and locks moisture into the skin at multiple depths (surface and deeper layers depending on molecular weight), creating a plumping, smoothing, and hydrating effect.

Why It's Used: It is used because it is endogenous to human skin, making it exceptionally biocompatible and non-irritating. its unparalleled moisture-binding capacity makes it the most effective hydrating ingredient available.

How It Works: Ha binds water molecules through its many hydroxyl and carboxyl groups, creating a gel-like matrix. high molecular weight ha (>500 kda) hydrates the skin surface; low molecular weight ha (<50 kda) penetrates deeper to provide interior hydration.

Typically Found In: Serums,moisturizers,sheet masks,toners,eye creams,lip treatments,dermal fillers (injectable)

TECHNICAL DETAILS

Primary Category: Active ingredient – humectant/hydrator

Secondary Functions: Barrier repair,plumping,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2% (effective at very low concentrations; multi-weight ha provides superior results)

SOURCING & ETHICS

Vegan Status: Yes – biotechnology-derived (microbial fermentation of streptococcus equi or b. subtilis); vegan-certified versions widely available

Halal Status: Yes

Source Notes: Originally extracted from rooster combs; now predominantly produced via biotechnology (bacterial fermentation), which is vegan and more sustainable.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; one of the gentlest skincare ingredients known

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: In very dry environments, high-molecular-weight ha on the surface can potentially draw moisture out of the skin if not sealed with an occlusive. apply to damp skin and seal with moisturizer.

Safe for Sensitive Skin: Yes – ideal for all skin types including rosacea, eczema, and post-procedure skin

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. endogenous molecule – no toxicity concerns. ewg hazard score: 1. safe during pregnancy.

Works Well With: Virtually all ingredients; especially ceramides,glycerin,peptides,retinol (reduces irritation),niacinamide,vitamin c

Avoid Combining With: No significant incompatibilities; high concentrations of alcohol in a formula may reduce its efficacy

SCIENTIFIC NOTE

Hyaluronic acid naturally degrades in skin (half-life ~1–2 days). the skin produces it endogenously, but production decreases with age. multi-molecular-weight ha formulas provide hydration at both surface and deeper skin levels.

Last Verified: Cosing database,cir safety assessment,papakonstantinou et al. (2012) dermato-endocrinology

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Hydroxycitronellal has an established safety profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,hydroxycitronellal technical literature

Primary Sources: 2026-03-12