Micro Essence Treatment Lotion Toner Fresh with Sakura Ferment

DESCRIPTION

What It Does: Inhibits neuromuscular acetylcholine release for reduced facial muscle contraction and expression line formation.

Why It's Used: Enhanced argireline analog with improved stability for formulations requiring optimized neuro-inhibiting anti-wrinkle performance.

How It Works: Competes with snap-25 protein for binding to the snare complex, reducing vesicular acetylcholine release at neuromuscular junctions. reduced acetylcholine binding decreases muscle contraction amplitude, reducing expression line depth with repeated use.

Typically Found In: Anti-wrinkle creams,expression line treatments,forehead/eye area products

TECHNICAL DETAILS

Primary Category: Active ingredient – neurotransmitter-inhibiting peptide

Secondary Functions: Enhanced snare inhibition,improved stability

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 3–1000 ppm

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetically produced. encapsulation may improve delivery to neuromuscular junction.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,moisturizers

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Hexapeptide-8 differs from argireline (hexapeptide-3) in its c-terminal modification that increases resistance to enzymatic degradation by skin proteases. this improved stability extends the bioavailability of the active peptide at the neuromuscular junction, potentially improving clinical anti-wrinkle efficacy vs the original argireline.

Last Verified: Cosing database,lipotec argireline plus data

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antioxidant protection from reactive oxygen species, reduces inflammatory cytokine production in skin, and conditions skin surface through the plant's secondary metabolite complex.

Why It's Used: Chosen for its natural origin narrative, traditional use heritage, and multi-functional phytochemical profile that supports several concurrent skin care claims from one ingredient.

How It Works: Polyphenols, terpenoids, and alkaloids in the extract scavenge ros via hydrogen atom transfer, inhibit nf-kb or cox-2 inflammatory pathways, and interact with skin surface proteins for conditioning.

Typically Found In: Botanical skin care,natural products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Plant secondary metabolites evolved as uv photoprotectants and antimicrobial agents — mechanisms that directly translate to cosmetic antioxidant and anti-inflammatory activity in human skin.

Last Verified: Cosing database,algae extract botanical review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Supports skin microbiome balance, delivers anti-inflammatory postbiotic metabolites, and provides biotransformed botanical actives with 10–50× improved sc penetration versus native glycoside forms.

Why It's Used: Preferred over live probiotic formats for conventional cosmetic stability and preservation compatibility, while delivering equivalent microbiome-supportive postbiotic metabolites.

How It Works: Multi-organism fermentation produces organic acids (acidifying skin surface ph to 4.5–5.5), bacteriocins, and β-glucosidases that deglycosylate botanical polyphenols to their more penetrant aglycone forms. tlr2-active cell wall fragments train skin immune cells toward anti-inflammatory tolerance.

Typically Found In: Microbiome skin care,anti-inflammatory

TECHNICAL DETAILS

Primary Category: Active ingredient – skin microbiome support

Secondary Functions: Microbiome balance,prebiotic effect

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–15%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Fermentation-derived or plant-extracted.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; beneficial for sensitive skin.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,niacinamide,soothing actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Multi-organism postbiotic biotransformation selectively generates free aglycone polyphenols with 30–50 da lower molecular weight and higher logp for significantly improved stratum corneum penetration.

Last Verified: Cosing database,multi-organism ferment postbiotic review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides humectant hydration and active ingredient solubilization with excellent skin feel.

Why It's Used: Preferred glycol humectant in premium and k-beauty formulations for superior skin feel vs propylene glycol with equivalent functionality.

How It Works: Two hydroxyl groups at 1,3-positions provide water binding and solvent activity. better tolerated than propylene glycol with minimal sensitization risk. 4-carbon backbone provides slightly greater hydrophobic character enabling dissolution of less polar actives vs pg.

Typically Found In: Toners,essences,serums,k-beauty formulas

TECHNICAL DETAILS

Primary Category: Functional ingredient – glycol humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–10%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

K-beauty's preference for butylene glycol over propylene glycol is driven by two factors: bg's superior skin feel (less tacky than pg's higher viscosity) and its lower sensitization potential (1,3-bg has better spatial distribution of hydroxyl groups that reduces protein interaction vs pg's 1,2-position oh groups).

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides postbiotic benefits including barrier support, anti-inflammatory, and microbiome-balancing activity from lactic acid bacteria ferment.

Why It's Used: Postbiotic ingredient for microbiome-supportive skincare addressing the growing evidence for skin microbiome dysbiosis in inflammatory skin conditions.

How It Works: Lactobacillus-derived exopolysaccharides and peptides activate toll-like receptors tlr2/tlr6 on keratinocytes upregulating antimicrobial peptide production. lipoteichoic acid (lta) component modulates immune response reducing pro-inflammatory cytokine production. lactic acid component maintains skin acidic ph.

Typically Found In: Probiotic skincare,microbiome-supportive products,sensitive skin formulas

TECHNICAL DETAILS

Primary Category: Active ingredient – skin microbiome support

Secondary Functions: Tlr2/tlr6 activation,amp upregulation,microbiome support

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes – bacterial fermentation

Halal Status: Yes

Source Notes: Fermentation-derived or plant-extracted.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; beneficial for sensitive skin.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,niacinamide,soothing actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Topical application of heat-killed (pasteurized) lactobacillus demonstrates comparable or superior efficacy to live bacteria for skin benefits in controlled studies – the active components (exopolysaccharides, lta, cell wall components) are heat-stable, and live bacteria in cosmetics face regulatory and stability challenges.

Last Verified: Cosing database,seite & misery microbiome skin review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antioxidant protection from reactive oxygen species, reduces inflammatory cytokine production in skin, and conditions skin through the plant's phytochemical complex.

Why It's Used: Natural origin narrative, traditional use heritage, and multi-functional phytochemical profile supporting concurrent skin care claims from one ingredient.

How It Works: Polyphenols, terpenoids, and alkaloids scavenge ros via h• donation, inhibit nf-kb or cox-2 inflammatory pathways, and interact with skin surface proteins for conditioning.

Typically Found In: Botanical skin care,natural products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Plant secondary metabolites evolved as photoprotectants and antimicrobials — mechanisms directly applicable to cosmetic antioxidant and anti-inflammatory activity in human skin.

Last Verified: Cosing database,laminaria saccharina extract botanical review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides humectant and solvent functionality from sustainable corn-based fermentation.

Why It's Used: Bio-based propylene glycol alternative from renewable corn — propanediol provides equivalent functionality to propylene glycol with sustainable renewable feedstock and superior skin feel.

How It Works: Two oh groups provide humectant water binding. excellent solvent for fragrances, actives, and preservatives. mild antimicrobial from diol structure for preservative system boosting. renew corn fermentation origin (dupont zemea process). better skin feel than propylene glycol — less sticky.

Typically Found In: Virtually all cosmetic categories as pg alternative

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–20%

SOURCING & ETHICS

Vegan Status: Yes – from corn sugar fermentation

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Propanediol's dupont tate & lyle bio products 'zemea' process ferments corn sugar to 1,3-propanediol using engineered e. coli — one of the first commercially viable bio-fermentation routes to a cosmetic diol previously made only from petroleum. the renewable route produces chemically identical 1,3-propanediol while reducing carbon footprint by approximately 40% vs petrochemical synthesis.

Last Verified: Cosing database,dupont tate & lyle zemea technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antioxidant protection from polyphenol radical scavenging, anti-inflammatory activity from terpenoid nf-kb/cox pathway inhibition, and skin conditioning from the secondary metabolite complex.

Why It's Used: Prunus lannesiana flower extract is selected for the characteristic secondary metabolite signature of prunus lannesiana — whether polyphenols, terpenoids, alkaloids, or polysaccharides, the phytochemical profile provides antioxidant, anti-inflammatory, or skin conditioning benefits specific to this botanical species.

How It Works: Polyphenol catechol h-atom donation for ros scavenging (10⁶-10⁹ m⁻¹s⁻¹); terpenoids inhibit iκb kinase; flavonoids compete at cox-1/2; alkaloids modulate specific receptor targets.

Typically Found In: Botanical skin care

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Conditional

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Standardise to marker compounds for consistent bioactivity — field-grown material varies 3-10× in secondary metabolite content.

Last Verified: Cosing database,prunus lannesiana flower extract botanical extract review

Primary Sources: 2026-03-22

DESCRIPTION

What It Does: Provides hyaluronic acid hydration in the most formulation-stable and compatible form.

Why It's Used: The standard form of ha used in cosmetics – more stable than free ha, better solubility, and equivalent skin hydration benefits.

How It Works: Sodium salt reduces the polyelectrolyte repulsion of ha chains, allowing better packing in formulations. on skin, sodium ions dissociate and the ha chain unfolds to its full water-binding conformation. provides full ha humectant and barrier benefits equivalent to free ha.

Typically Found In: Hydrating serums,toners,moisturizers,sheet masks,anti-aging products

TECHNICAL DETAILS

Primary Category: Active ingredient – ha sodium salt

Secondary Functions: Equivalent ha hydration,superior stability

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – bacterial fermentation

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

The sodium salt form of ha has approximately 10% better water solubility than free hyaluronic acid at equivalent molecular weight due to reduced chain-chain electrostatic repulsion from partial sodium counterion screening. this improved solubility enables higher concentration formulations without viscosity issues.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12