Nature Republic Black Bean Anti Hair Loss Root Shampoo

DESCRIPTION

What It Does: Provides documented cosmetic activity from coco-betaine.

Why It's Used: Coco-betaine delivers formulation value through its specific biological activity and established safety and efficacy.

How It Works: Source: coco-betaine. mechanism: documented in cosmetic literature. safety: cosing-reviewed. standard cosmetic use concentrations.

Typically Found In: Skin care formulations,active products

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Coco-betaine provides cosmetic activity through its characteristic mechanism. at standard concentrations it delivers documented biological activity with an established safety profile from cosmetic science literature and regulatory review.

Last Verified: Cosing database,coco-betaine technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30% (typical: 3–10%)

SOURCING & ETHICS

Vegan Status: Yes – plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes – when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Activates trpm8 cold thermoreceptors for intense cooling sensation and analgesic activity.

Why It's Used: The most potent cosmetic cooling agent – direct trpm8 agonist providing cooling sensation without actual temperature reduction for refreshing and analgesic formulations.

How It Works: Potent trpm8 (menthol receptor/cold thermosensor) agonist – activation at room temperature mimics cold sensation without actual cooling. anti-pruritic via trpm8 activation competing with itch c-fiber signaling. antimicrobial via membrane disruption.

Typically Found In: Cooling products,scalp treatments,oral care,pain relief,foot care,after-sun

TECHNICAL DETAILS

Primary Category: Active ingredient – cooling sensory terpenoid

Secondary Functions: Redness reduction,anti-inflammatory,calming

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – from mentha piperita or synthetic

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate; potential sensitizer

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Avoid near eyes. use with caution at concentrations above 1% for sensitive skin.

SAFETY & COMPATIBILITY

Safety Profile: Eu max 4.5% (leave-on); regulations vary by application site. avoid on infants' face.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Menthol's exceptional cooling potency stems from its ec50 for trpm8 activation of approximately 10μm (vs camphor's ec50 of ~5mm – 500× lower potency). this 500× potency advantage explains why even tiny concentrations of menthol provide intense cooling, while much higher concentrations of camphor are required for equivalent sensation.

Last Verified: Cosing database,mckemy et al. menthol trpm8 discovery,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Niacinamide strengthens the skin barrier, reduces visible pore size, regulates sebum production, fades dark spots, and improves skin texture and tone.

Why It's Used: It is used because it addresses multiple skin concerns at once without irritation, making it suitable for all skin types. it is stable in formulations and pairs well with most other actives.

How It Works: Niacinamide inhibits the transfer of melanosomes (pigment packets) to skin cells, reducing hyperpigmentation. it also stimulates ceramide synthesis to strengthen the skin barrier and reduces inflammation by modulating cytokine activity.

Typically Found In: Serums,moisturizers,toners,cleansers,eye creams,sunscreens,primers

TECHNICAL DETAILS

Primary Category: Active ingredient – vitamin

Secondary Functions: Barrier repair,brightening,anti-inflammatory

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 2%–10% (typical: 5%; higher concentrations may cause flushing in some individuals)

SOURCING & ETHICS

Vegan Status: Yes – synthetically produced

Halal Status: Yes – synthetic origin

Source Notes: Commercially produced via synthesis from nicotinic acid or 3-cyanopyridine. no animal-derived sources used in cosmetic-grade niacinamide.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; concentrations above 10% may cause temporary flushing in sensitive individuals

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: At concentrations >10%, some users experience niacin flush (transient redness/tingling). generally very well-tolerated.

Safe for Sensitive Skin: Yes – one of the best-tolerated actives for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Extensively studied and considered very safe. ewg hazard score: 1. no significant systemic toxicity concerns at topical concentrations.

Works Well With: Retinol,peptides,ahas/bhas,hyaluronic acid,ceramides,zinc,vitamin c,spf

Avoid Combining With: High concentrations of vitamin c (ascorbic acid) may theoretically convert to niacin – use at different times if using pure l-ascorbic acid above 15%

SCIENTIFIC NOTE

Niacinamide is a precursor to nad+ and nadp+, coenzymes vital to cellular energy metabolism. its benefits for dna repair and mitochondrial function make it a key ingredient in anti-aging strategies.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,pubmed clinical studies

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Niacinamide strengthens the skin barrier, reduces visible pore size, regulates sebum production, fades dark spots, and improves skin texture and tone.

Why It's Used: It is used because it addresses multiple skin concerns at once without irritation, making it suitable for all skin types. it is stable in formulations and pairs well with most other actives.

How It Works: Niacinamide inhibits the transfer of melanosomes (pigment packets) to skin cells, reducing hyperpigmentation. it also stimulates ceramide synthesis to strengthen the skin barrier and reduces inflammation by modulating cytokine activity.

Typically Found In: Serums,moisturizers,toners,cleansers,eye creams,sunscreens,primers

TECHNICAL DETAILS

Primary Category: Active ingredient – vitamin

Secondary Functions: Barrier repair,brightening,anti-inflammatory

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 2%–10% (typical: 5%; higher concentrations may cause flushing in some individuals)

SOURCING & ETHICS

Vegan Status: Yes – synthetically produced

Halal Status: Yes – synthetic origin

Source Notes: Commercially produced via synthesis from nicotinic acid or 3-cyanopyridine. no animal-derived sources used in cosmetic-grade niacinamide.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; concentrations above 10% may cause temporary flushing in sensitive individuals

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: At concentrations >10%, some users experience niacin flush (transient redness/tingling). generally very well-tolerated.

Safe for Sensitive Skin: Yes – one of the best-tolerated actives for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Extensively studied and considered very safe. ewg hazard score: 1. no significant systemic toxicity concerns at topical concentrations.

Works Well With: Retinol,peptides,ahas/bhas,hyaluronic acid,ceramides,zinc,vitamin c,spf

Avoid Combining With: High concentrations of vitamin c (ascorbic acid) may theoretically convert to niacin – use at different times if using pure l-ascorbic acid above 15%

SCIENTIFIC NOTE

Niacinamide is a precursor to nad+ and nadp+, coenzymes vital to cellular energy metabolism. its benefits for dna repair and mitochondrial function make it a key ingredient in anti-aging strategies.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,pubmed clinical studies

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides film-forming conditioning and detangling with heat protection in a polymer that adsorbs substantively to hair.

Why It's Used: The most widely used cationic polymer conditioner – provides excellent conditioning and detangling while adsorbing strongly to damaged hair areas that need conditioning most.

How It Works: Cationic quaternary ammonium groups along the polymer backbone adsorb to anionic sites on hair keratin. higher charge density on damaged hair (more negative sites) leads to preferential adsorption where conditioning is needed. polymer film formation provides heat protection and volume.

Typically Found In: Shampoos,2-in-1 products,conditioners,styling products

TECHNICAL DETAILS

Primary Category: Functional ingredient – cationic polymer conditioner

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – cellulose-derived

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Polyquaternium-10's 'self-targeting' to damaged hair sites is a unique smart conditioning mechanism. as hair damage increases negative charge density by exposing keratin's aspartate and glutamate carboxylate groups, pq-10's cationic polymer backbone adsorbs preferentially to these high-charge damage sites – automatically delivering more conditioning where the hair needs it most.

Last Verified: Cosing database,robbins hair science,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the universal solvent and vehicle for water-soluble actives and the continuous phase of all o/w emulsions.

Why It's Used: The most essential cosmetic ingredient — aqua (water) is listed first on virtually all water-containing cosmetic inci labels as the highest-concentration ingredient, serving as the foundation of the global cosmetics industry.

How It Works: Acts as solvent for all water-soluble ingredients (glycols, amino acids, water-soluble actives). forms the continuous external phase of o/w emulsions (lotions, creams, serums). provides aqueous environment for enzymatic and chemical reactions between actives. ph adjustment medium.

Typically Found In: Virtually all cosmetic products — the most universal cosmetic ingredient globally

TECHNICAL DETAILS

Primary Category: Functional ingredient – water

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: Varies widely — up to 95% in some toners and serums

SOURCING & ETHICS

Vegan Status: Yes – water (deionised/purified)

Halal Status: Yes

Source Notes: Cosmetic-grade water is purified (deionised, distilled, or ro filtered) to prevent mineral content interference with formulation stability. european pharmacopoeial water (aqua purificata ph. eur.) is the quality standard for pharmaceutical and high-end cosmetic formulations.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – non-irritant

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Water's position as the first inci ingredient on most cosmetic labels reflects the regulatory requirement to list ingredients in descending concentration order — meaning water is the most abundant ingredient in the majority of cosmetic products. the fundamental role of water as the universal cosmetic solvent and vehicle makes it simultaneously the most important cosmetic ingredient and the one that requires the most sophisticated formulation chemistry to control — every emulsifier, thickener, preservative, and ph adjuster exists primarily to manage water's interaction with other ingredients in formulation.

Last Verified: Cosing database,eu cosmetics regulation 1223/2009 inci requirements,ph. eur. aqua purificata monograph

Primary Sources: 2026-03-12