Neutrogena Ultra Gentle Daily Face Moisturizer |Glycerin, Niacinamide, Vitamin B5 for Sensitive Skin, 100 ml

DESCRIPTION

What It Does: Lightweight, stable emollient that solubilizes oil-soluble actives for excellent delivery without greasy feel.

Why It's Used: Universal lightweight emollient base and solubilizer for oil-soluble actives in serums and low-viscosity formulations where mineral oil or petrolatum would be too heavy.

How It Works: Medium-chain length provides ideal balance of spreading coefficient, penetration rate, and barrier-sealing properties. excellent solubilizer for vitamin e, retinoids, and other lipophilic actives.

Typically Found In: Serums,facial oils,sunscreens,anti-aging products,hair products

TECHNICAL DETAILS

Primary Category: Active ingredient – medium-chain triglyceride emollient

Secondary Functions: Active solubilizer,spreading agent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–50%

SOURCING & ETHICS

Vegan Status: Yes – from coconut/palm kernel oil

Halal Status: Yes

Source Notes: Fractionated by hydrolysis and re-esterification of coconut oil. only c8 and c10 fatty acids retained.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – very low; medium-chain length generally non-comedogenic

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Mct oil's medium-chain length (c8/c10) provides superior oxidative stability vs longer polyunsaturated chains and better skin aesthetics (lighter, less greasy) vs longer chain emollients (c16/c18). excellent solubilizer for retinoic acid, tocopheryl esters, and other lipophilic actives.

Last Verified: Cosing database,cir safety assessment,ewg skin deep

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the most potent antimicrobial diol activity alongside skin feel enhancement.

Why It's Used: Premium antimicrobial diol — caprylyl glycol's c8 chain provides the strongest membrane-disrupting antimicrobial activity of common diol preservative boosters with unique skin-feel enhancement.

How It Works: C8 1,2-diol: c8 chain length provides strongest bacterial and fungal membrane disruption of common diols. emollient skin feel improvement from c8 chain length interaction with skin surface. active at lower concentrations than shorter-chain diols. synergistic with ethylhexylglycerin.

Typically Found In: Natural preservation systems,skin feel enhancement

TECHNICAL DETAILS

Primary Category: Functional ingredient – antimicrobial humectant

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–1%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Caprylyl glycol's antimicrobial potency follows the chain-length dependent membrane activity of fatty acids: c8 is the optimal chain length for membrane disruption (same as caprylic acid's antimicrobial optimum), providing maximum membrane integration without the skin sensitisation associated with longer chain lengths. this chain-length pharmacophore relationship is why c8 > c6 > c5 in diol antimicrobial potency despite identical head group chemistry.

Last Verified: Cosing database,schülke sensiva sc 50 technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides transparent gel textures and thickening at very low concentrations via ph-responsive swelling.

Why It's Used: The most widely used gel thickener – provides crystal-clear, stable gels at concentrations as low as 0.1-0.5% with ph-controlled viscosity.

How It Works: Highly crosslinked polyacrylic acid remains tightly coiled at acidic ph. neutralization with naoh or triethanolamine ionizes carboxylic groups causing electrostatic repulsion that unfolds and swells the polymer coils, dramatically increasing viscosity. concentration-dependent thickening.

Typically Found In: Gels,serums,emulsions,sunscreens

TECHNICAL DETAILS

Primary Category: Functional ingredient – polyacrylic acid thickener

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Carbomer's ph-responsive swelling mechanism provides an elegant formulation control tool: a neutralized gel can be liquefied by ph reduction (adding acid) and re-thickened by reneutralization. this reversible rheology control allows two-phase products that mix on application without the need for mechanical emulsification.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides high-hlb o/w emulsification for stable cream formation from ethoxylated cetearyl alcohol.

Why It's Used: Classic self-emulsifying wax component for standard pharmaceutical and cosmetic cream formulation.

How It Works: 20 eo units on cetearyl alcohol chain provide hlb ~15-17 for strong o/w emulsification. often pre-blended with cetearyl alcohol as 'emulsifying wax' for simplified cream making. combined low-hlb cetearyl alcohol + high-hlb ceteareth-20 forms a balanced self-emulsifying system.

Typically Found In: Classic pharmaceutical and cosmetic creams

TECHNICAL DETAILS

Primary Category: Functional ingredient – ethoxylated fatty alcohol emulsifier

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–8%

SOURCING & ETHICS

Vegan Status: Conditional – peg petroleum; cetearyl vegetable

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Ceteareth-20's combination with cetearyl alcohol in the classic 'emulsifying wax nf' creates what is called a 'mixed emulsifier system' where the fatty alcohol forms lamellar crystal phases that physically trap and stabilize oil droplets. this physical (lamellar crystal) + chemical (hlb balance) dual stabilization provides superior stability compared to either component alone.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides fatty alcohol emulsification and thickening for stable, well-textured emulsions.

Why It's Used: The most widely used fatty alcohol in cosmetics – provides emulsification, thickening, and emolliency simultaneously from a single ingredient with excellent safety profile.

How It Works: Forms bilayer lamellar structures in water with emulsifiers creating a viscous structured network that thickens and stabilizes emulsions. fatty alcohol emolliency provides direct skin conditioning. bilayer formation reduces inter-droplet coalescence in emulsions.

Typically Found In: Creams,lotions,conditioners – virtually all emulsion products

TECHNICAL DETAILS

Primary Category: Functional ingredient – fatty alcohol emulsifier/thickener

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–25%

SOURCING & ETHICS

Vegan Status: Yes – from vegetable or coconut/palm fatty acids

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Cetearyl alcohol's ability to form lamellar liquid crystal structures ('krafft phases') with water and co-emulsifiers provides not only emulsion stability but also enhanced skin penetration via the lamellar skin barrier pathway. these crystalline structures can act as a reservoir for active ingredients, slowly releasing them as the lamellar structure melts on skin contact.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides c16 fatty alcohol emolliency and thickening for well-textured cosmetic emulsions.

Why It's Used: Lighter-textured fatty alcohol alternative to stearyl alcohol for creams and conditioners requiring less heavy emolliency.

How It Works: C16 chain length provides slightly lower melting point (49°c) than stearyl (60°c) giving softer, lighter emulsion texture. forms lamellar networks for thickening and stability. direct skin and hair conditioning via fatty alcohol film.

Typically Found In: Creams,hair conditioners,lotions

TECHNICAL DETAILS

Primary Category: Functional ingredient – fatty alcohol

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–15%

SOURCING & ETHICS

Vegan Status: Yes – from vegetable or coconut/palm fatty acids

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Cetyl alcohol's c16 chain length is at the approximate thermal transition point for fatty alcohol lamellar crystallization at skin temperature (33°c). this transition (from ordered crystalline to disordered liquid phase near skin temperature) provides the characteristic 'melts on application' sensory profile that makes cetyl alcohol-containing products feel cooling and light on initial application.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides gram-negative focused preservation complementary to phenoxyethanol for comprehensive spectrum coverage.

Why It's Used: Phenoxyethanol complement — chlorphenesin's gram-negative and antifungal coverage complements phenoxyethanol's gram-positive activity for full-spectrum preservation at lower individual concentrations.

How It Works: 4-chlorophenol ether glycol disrupts bacterial and fungal membranes. strong gram-negative activity (pseudomonas, e. coli). good candida antifungal activity. used with phenoxyethanol for synergistic broad-spectrum coverage. ph stable 3-9.

Typically Found In: Comprehensive preservation systems,baby products (low concentration)

TECHNICAL DETAILS

Primary Category: Functional ingredient – glycerol ether preservative

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–0.3%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu max 0.3% cosmetics. good safety profile. synergistic combination with phenoxyethanol (0.3% pe + 0.1% chlorphenesin often equivalent to 1% pe alone).

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Chlorphenesin + phenoxyethanol synergy operates through a classic spectrum-filling combination: phenoxyethanol provides strong gram-positive antimicrobial activity while chlorphenesin provides gram-negative and antifungal coverage. the combination's minimum inhibitory concentration sum is subadditive (provides equivalent preservation at combined concentrations below what either alone would require) — textbook pharmacological synergy enabling lower total preservative load.

Last Verified: Cosing database,eu preservative annex v,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Adjusts ph to optimal ranges, chelates destabilizing metal ions, provides mild exfoliation at higher concentrations.

Why It's Used: Universal cosmetic ph adjuster and chelating agent. aha exfoliant activity is secondary.

How It Works: As ph adjuster, donates protons. as chelating agent, three carboxylic groups bind divalent metals (ca²⁺, mg²⁺, fe²⁺) preventing oxidative degradation.

Typically Found In: Nearly all cosmetic formulations,brightening products,exfoliants

TECHNICAL DETAILS

Primary Category: Active ingredient – alpha hydroxy acid (aha)

Secondary Functions: Chelating agent,ph adjustment,preservation enhancement

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Yes – synthetic or fermentation-derived

Halal Status: Yes

Source Notes: Produced by fermentation of sugars by aspergillus niger. gras (e330). most abundant organic acid in citrus.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low at low concentrations; 2/5 at exfoliant concentrations

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Photosensitizing – mandatory spf use. start at low frequency.

Safe for Sensitive Skin: Use with caution – spf required

SAFETY & COMPATIBILITY

Safety Profile: Safe at otc concentrations. eu: ≤10% leave-on at ph ≥3.5. mandatory spf advisory.

Works Well With: Niacinamide,ceramides,hyaluronic acid,spf

Avoid Combining With: Retinol in same step; multiple exfoliants simultaneously

SCIENTIFIC NOTE

Three carboxylic acid groups provide multiple proton donation sites and stronger chelation than monocarboxylic ahas. this makes citric acid the preferred cosmetic chelating agent alongside edta.

Last Verified: Cosing database,cir safety assessment,ewg skin deep

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Dicaprylyl ether has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,dicaprylyl ether technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides silicone-characteristic silky feel and skin protection with adjustable viscosity.

Why It's Used: The benchmark cosmetic silicone – sets the gold standard for silky application feel, spreadability, and skin protection in virtually all skin care categories.

How It Works: Polydimethylsiloxane chain flexibility provides extremely low surface tension and high spreadability. inert si-o backbone provides chemical stability and excellent skin tolerance. occlusive film formation reduces tewl. higher viscosity grades provide more intense conditioning.

Typically Found In: Moisturizers,foundations,primers,sunscreens – nearly universal

TECHNICAL DETAILS

Primary Category: Functional ingredient – polydimethylsiloxane

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–30%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Dimethicone's exceptional silky feel arises from its very low intermolecular attractive forces (weak van der waals forces due to non-polar methyl groups) that allow silicone chains to slide freely over skin. the coefficient of kinetic friction for pdms against skin (~0.04) is among the lowest of any cosmetic material – explaining why even small amounts transform product feel.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12