Ozone
Ozone Signature Tran-AZ Serum
Ozone Signature Tran-AZ Serum
Ozone
ozone-signature-tran-az-serum
Serum
10085495243045
Morning or Evening?
How often will you use this product?
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Highlights
WHAT IS IT?
Serum with 2 key actives
FEATURES
Repairs skin discoloration, scarring, and uneven skin tone; Contains 3% tranexamic acid and 2% azelaic acid; Reduces dark spots and hyperpigmentation; Suitable for men and women
BEST FOR
sensitive
CHECKS
never tested on animals, non-toxic, hypo-allergenic (HRIPT)
Who Is It For?
Men And Women No Specific Age Range StatedWhat Does It Help With?
Reduces Dark Spots Hyperpigmentation Uneven Skin Tone Skin Discoloration ScarringBudget
Mid-range ($30-$75)How To Use
Which routine should it be used in?
Instructions:
Key Information
What Ozone Says
Product Description:
Ozone Signature Serum Tran-Az is formulated to repair skin discoloration, scarring, and uneven skin tone. The serum combines 3% tranexamic acid and 2% azelaic acid to reduce dark spots and hyperpigmentation. Suitable for both men and women.
About the Brand:
Ingredients Overview
Ingredients List
3%-tranexamic-acid,2%-azelaic-acid
Key Ingredients
tranexamic acid, azelaic acid
Ingredients Details
Azelaic Acid
Common Name(s): Nonanedioic acid,lepargylic acid
CAS Number: 123-99-9
DESCRIPTION
What It Does: Reduces acne, evens skin tone, calms rosacea, and reduces hyperpigmentation through multiple complementary mechanisms.
Why It's Used: Multi-action gold standard for hyperpigmentation, acne, rosacea, and post-inflammatory hyperpigmentation (pih) โ well-tolerated by all skin tones.
How It Works: Inhibits tyrosinase (melanin synthesis) and abnormal melanocyte proliferation. inhibits 5-alpha-reductase (sebum control). antimicrobial against p. acnes and malassezia. anti-inflammatory via nf-kb pathway inhibition.
Typically Found In: Brightening serums,anti-acne treatments,rosacea products,hyperpigmentation formulations
TECHNICAL DETAILS
Primary Category: Active ingredient โ dicarboxylic acid
Secondary Functions: Anti-acne,rosacea management,sebum control
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 5%โ20% (otc 5โ10%; prescription 15โ20%)
SOURCING & ETHICS
Vegan Status: Yes โ synthetic or from wheat/rye
Halal Status: Yes
Source Notes: Naturally from malassezia yeast on skin; produced by ozonolysis of oleic acid commercially.
SKIN COMPATIBILITY
Irritancy Rating: 2/5 โ low to moderate; initial tingling expected
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Initial tingling and stinging normalizes within 2โ4 weeks of regular use.
Safe for Sensitive Skin: Use with caution โ transient tingling common during introduction
SAFETY & COMPATIBILITY
Safety Profile: Excellent long-term safety. fda-approved for acne (benzaclin) and rosacea (finacea). ewg score: 1.
Works Well With: Ceramides,niacinamide,hyaluronic acid,spf
Avoid Combining With: Multiple exfoliating acids simultaneously; high concentrations without spf
SCIENTIFIC NOTE
Azelaic acid's combined tyrosinase inhibition + abnormal melanocyte selectivity (normalizes only overactive melanocytes, unlike hydroquinone) makes it uniquely safe for long-term use without bleaching normal-pigmented skin.
Last Verified: Cosing database,draelos azelaic acid review,fda drug approval database
Primary Sources: 2026-03-12
Tranexamic Acid
Common Name(s): Trans-4-aminomethylcyclohexanecarboxylic acid,txa,cyklokapron
CAS Number: 1197-18-8
DESCRIPTION
What It Does: Provides brightening by inhibiting uv-induced plasminogen activation that triggers melanocyte stimulation.
Why It's Used: Novel brightening mechanism โ tranexamic acid targets uv-induced melanocyte stimulation upstream of tyrosinase activity, providing complementary brightening to tyrosinase inhibitors with exceptional tolerability.
How It Works: Lysine analogue binds lysine-binding sites on plasminogen preventing its conversion to plasmin. uv-activated plasmin normally increases keratinocyte arachidonic acid release stimulating melanocyte activity via prostaglandin e2 and alpha-msh. txa blocks this uv-melanocyte signalling cascade upstream of pigment synthesis.
Typically Found In: Brightening serums,anti-melasma products,uv-induced pigmentation
TECHNICAL DETAILS
Primary Category: Active ingredient โ lysine analogue brightening
Secondary Functions: Melanin inhibition,hyperpigmentation reduction
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ5%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic
Halal Status: Yes
Source Notes: Synthetic or plant-derived.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. use with spf for maximum efficacy. ewg score: 1.
Works Well With: Niacinamide,vitamin c,alpha-arbutin,tranexamic acid,spf
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Tranexamic acid's brightening mechanism was discovered serendipitously โ it was originally a haemostasis drug for reducing surgical bleeding. dermatologists noted that patients receiving txa for bleeding showed improved melasma, leading to investigation that revealed the plasminogenโprostaglandinโmelanocyte signalling cascade as a completely previously unknown brightening target.
Last Verified: Cosing database,huang et al. tranexamic acid brightening review
Primary Sources: 2026-03-12