Replenish Hydrating Cream

SkinMedica

Replenish Hydrating Cream

Replenish Hydrating Cream

SkinMedica

replenish-hydrating-cream

Moisturize

9643650810149

Morning or Evening?

Morning
Evening
Both

How often will you use this product?

Everyday
Every other day
Every 3 days
Every 4 days
Every 5 days
Every 6 days
Once a week
Twice a week
On specific days
As needed
On rotation

Notes

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Compatibility Score

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Highlights

WHAT IS IT?

Hydrating cream moisturizer

FEATURES

Hydrates, refreshes, soothes and nourishes sensitive skin

BEST FOR

Sensitive skin

CHECKS

Free of parabens

Who Is It For?

Adults Both Men And Women

What Does It Help With?

Hydration Soothing Sensitive Skin

Budget

Mid-range

How To Use

Which routine should it be used in?

Morning
Evening
 
Cleanse
Tone
Eyecare
Serum
Moisturize
Suncare
 

Instructions:

Apply twice daily in the morning and evening. Apply after cleansing, toning and treatment products, and before sunscreen in the a.m. Apply evenly over entire face (neck and chest if desired). Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.

Key Information

Vegan
Cruelty-free
Sensitive-safe
Non-comedogenic
Hypoallergenic
Microbiome-safe
Preservative-free
Eco-friendly
Pregnancy-safe
Oil-free

What SkinMedica Says

Product Description:

Hydrating Cream that hydrates as well as refreshes, soothes and nourishes sensitive skin.

About the Brand:

SkinMedica, an Allergan company, brings professional-grade skincare to your daily routine. With a foundation in decades of scientific research, this brand offers advanced skin rejuvenation products that harness your skin's natural healing abilities. Unveil your most radiant skin with formulations trusted by dermatologists and plastic surgeons alike.

Ingredients Overview

Ingredients List

Water/Aqua/Eau, Glycerin, Cyclopentasiloxane, Cetyl Alcohol, Stearyl Alcohol, Sucrose Cocoate, Isododecane, Isohexadecane, Cyclohexasiloxane, Glyceryl Stearate, PEG-100 Stearate, Microcrystalline Cellulose, Sodium PCA, Phytosterol Isostearate, Allantoin Glycyrrhetinic Acid, Tocopheryl Acetate, Ceramide NP, Polysilicone-11, Hydrolyzed Caesalpinia Spinosa Gum, Caesalpinia Spinosa Gum, Linoleic Acid, Linolenic Acid, Tocopherol, Panicum Miliaceum (Millet) Seed Extract, Bisabolol, Sodium Hyaluronate, Butylene Glycol, Camellia Oleifera Leaf Extract, Magnesium Ascorbyl Phosphate, Superoxide Dismutase, Cetyl Hydroxyethylcellulose, Cellulose Gum, Hydroxyacetophenone, Disodium EDTA, Ethylhexylglycerin, Phenoxyethanol

Key Ingredients

Superoxide Dismutase, Vitamin E, Bisabolol, Green Tea Leaf Extract, Sodium Hyaluronate, Vitamin C

Ingredients Details

Cetyl Alcohol

Common Name(s): 1-hexadecanol,palmityl alcohol,n-cetyl alcohol

CAS Number: 36653-82-4

DESCRIPTION

What It Does: Provides c16 fatty alcohol emolliency and thickening for well-textured cosmetic emulsions.

Why It's Used: Lighter-textured fatty alcohol alternative to stearyl alcohol for creams and conditioners requiring less heavy emolliency.

How It Works: C16 chain length provides slightly lower melting point (49ยฐc) than stearyl (60ยฐc) giving softer, lighter emulsion texture. forms lamellar networks for thickening and stability. direct skin and hair conditioning via fatty alcohol film.

Typically Found In: Creams,hair conditioners,lotions

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ fatty alcohol

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“15%

SOURCING & ETHICS

Vegan Status: Yes โ€“ from vegetable or coconut/palm fatty acids

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 1/5 โ€“ low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Cetyl alcohol's c16 chain length is at the approximate thermal transition point for fatty alcohol lamellar crystallization at skin temperature (33ยฐc). this transition (from ordered crystalline to disordered liquid phase near skin temperature) provides the characteristic 'melts on application' sensory profile that makes cetyl alcohol-containing products feel cooling and light on initial application.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

Cyclohexasiloxane

Common Name(s): D6,cyclomethicone d6,hexamethylcyclotrisiloxane

CAS Number: 540-97-6

DESCRIPTION

What It Does: Provides volatile silicone delivery with longer contact time than d5 for extended active delivery.

Why It's Used: Longer-evaporation volatile silicone for formulations requiring extended delivery contact time vs d5's rapid evaporation.

How It Works: Larger ring (6 silicone units) provides lower vapor pressure than d5 (5 units). slower evaporation rate (2-3ร— longer than d5) provides extended delivery window. same dry-touch after complete evaporation.

Typically Found In: Longer-duration volatile vehicles,serum formulations

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ volatile cyclic silicone

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“30%

SOURCING & ETHICS

Vegan Status: Yes โ€“ synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu restrictions on d5 do not apply to d6 โ€“ d6 may be used in rinse-off products without restriction.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

The different evaporation rates of d4 (methylcyclosiloxane), d5, and d6 provide formulators with a toolkit of volatile silicone delivery windows: d4 evaporates in ~1 minute, d5 in ~5 minutes, d6 in ~15 minutes. blending these provides precisely tunable evaporation kinetics for specific delivery timing requirements.

Last Verified: Cosing database,dow silicone technical data,cir safety assessment

Primary Sources: 2026-03-12

Cyclopentasiloxane

Common Name(s): Cyclopentasiloxane,cyclic volatile silicone,dry-touch carrier solvent

CAS Number: N/a

DESCRIPTION

What It Does: Provides a dry, weightless application vehicle that evaporates cleanly leaving actives and non-volatile silicones deposited on skin โ€” eliminating the residual heaviness of conventional liquid carrier solvents.

Why It's Used: Cyclosiloxanes are the unique volatile silicone solvents that dissolve non-volatile silicones (dimethicone, cyclomethicone), organic uv filters, and lipophilic actives, providing the sensory-superior dry-touch application experience in premium formulations.

How It Works: Cyclosiloxane vapour pressure (d5 cyclopentasiloxane ~0.3 mmhg at 25ยฐc) provides clean evaporation at body temperature. the cyclic ring structure provides lower boiling point than equivalent linear dimethicone, enabling faster evaporation while the ring conformation maintains the silicone's low surface energy for smooth application.

Typically Found In: Primers,antiperspirants,sunscreens

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ emollient

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“50%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 1/5 โ€“ low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Cyclopentasiloxane (d5) and cyclohexasiloxane (d6) are under eu regulatory review for potential environmental persistence (pbt assessment) โ€” formulators should monitor eu regulation 2018/35 implementation for restrictions in wash-off products.

Last Verified: Cosing database,eu cyclosiloxane regulatory review

Primary Sources: 2026-03-12

Glycerin

Common Name(s): Glycerol,glycerine,1,2,3-propanetriol

CAS Number: 56-81-5

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“30% (typical: 3โ€“10%)

SOURCING & ETHICS

Vegan Status: Yes โ€“ plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes โ€“ when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12