SOME BY MI Cica Peptide Anti Hair Loss Derma Scalp Tonic

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

1-2-hexanediol has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,1-2-hexanediol technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Accelerates wound healing and reduces scar formation through fibroblast activation and collagen synthesis stimulation.

Why It's Used: Clinically proven scar reduction and wound healing active – the compound behind centella's legendary wound healing reputation.

How It Works: Promotes fibroblast proliferation and collagen synthesis via tgf-β independent mechanism (distinct from madecassoside). also inhibits hyaluronidase protecting extracellular matrix. antimicrobial activity supports wound healing environment.

Typically Found In: Post-surgical products,scar treatments,wound healing formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Scar reduction,wound healing,collagen stimulation

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%–2%

SOURCING & ETHICS

Vegan Status: Yes – centella asiatica derived

Halal Status: Yes

Source Notes: Extracted from centella asiatica aerial parts alongside madecassoside, asiatic acid, and madecassic acid.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Asiaticoside's mechanism of wound healing involves release of aglycone asiatic acid after hydrolysis by skin beta-glucosidases. the glycoside form provides better stratum corneum penetration than the hydrophobic aglycone, acting as a prodrug for the active asiatic acid at the wound healing site.

Last Verified: Cosing database,bylka et al. centella asiatica review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Supports keratin production for stronger hair and nails.

Why It's Used: Hair and nail keratin infrastructure support; widely marketed despite evidence being primarily oral supplementation-based.

How It Works: Coenzyme for carboxylase enzymes essential for fatty acid synthesis and amino acid metabolism relevant to hair follicle function.

Typically Found In: Hair growth shampoos,nail treatments,multivitamin products

TECHNICAL DETAILS

Primary Category: Active ingredient – vitamin b7

Secondary Functions: Hair growth support,nail strengthening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%–0.5%

SOURCING & ETHICS

Vegan Status: Yes – synthetically produced

Halal Status: Yes

Source Notes: Synthetically produced for cosmetic use.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; excellent tolerability.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Other b vitamins,niacinamide,antioxidant complexes

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Evidence for topical biotin efficacy in hair growth is limited – most clinical evidence comes from oral supplementation in biotin-deficient individuals.

Last Verified: Cosing database,cir safety assessment,patel et al. (2017) skin appendage disorders

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Supports keratin production for stronger hair and nails.

Why It's Used: Hair and nail keratin infrastructure support; widely marketed despite evidence being primarily oral supplementation-based.

How It Works: Coenzyme for carboxylase enzymes essential for fatty acid synthesis and amino acid metabolism relevant to hair follicle function.

Typically Found In: Hair growth shampoos,nail treatments,multivitamin products

TECHNICAL DETAILS

Primary Category: Active ingredient – vitamin b7

Secondary Functions: Hair growth support,nail strengthening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%–0.5%

SOURCING & ETHICS

Vegan Status: Yes – synthetically produced

Halal Status: Yes

Source Notes: Synthetically produced for cosmetic use.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; excellent tolerability.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Other b vitamins,niacinamide,antioxidant complexes

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Evidence for topical biotin efficacy in hair growth is limited – most clinical evidence comes from oral supplementation in biotin-deficient individuals.

Last Verified: Cosing database,cir safety assessment,patel et al. (2017) skin appendage disorders

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antioxidant protection from reactive oxygen species, reduces inflammatory cytokine production in skin, and conditions skin surface through the plant's secondary metabolite complex.

Why It's Used: Chosen for its natural origin narrative, traditional use heritage, and multi-functional phytochemical profile that supports several concurrent skin care claims from one ingredient.

How It Works: Polyphenols, terpenoids, and alkaloids in the extract scavenge ros via hydrogen atom transfer, inhibit nf-kb or cox-2 inflammatory pathways, and interact with skin surface proteins for conditioning.

Typically Found In: Botanical skin care,natural products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Plant secondary metabolites evolved as uv photoprotectants and antimicrobial agents — mechanisms that directly translate to cosmetic antioxidant and anti-inflammatory activity in human skin.

Last Verified: Cosing database,centella asiatica extract botanical review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides tropoelastin-derived sequence for elastin synthesis and elastic fibre organisation.

Why It's Used: Elastin-specific anti-aging — most anti-aging peptides target collagen; hexapeptide-9's elastin specificity addresses the elastic fibre loss responsible for sagging that collagen peptides alone cannot correct.

How It Works: Tropoelastin-derived hexapeptide activates elastin synthesis in dermal fibroblasts. promotes normal elastic fibre organisation (crosslinked desmosine network). targets the elastic fibre loss underlying skin sagging unavailable from collagen-only peptide approaches.

Typically Found In: Anti-sagging serums,skin elasticity products

TECHNICAL DETAILS

Primary Category: Active ingredient – signal peptide

Secondary Functions: Collagen stimulation,skin firming,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.0001%–0.05%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide

Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)

SCIENTIFIC NOTE

Skin sagging arises primarily from elastic fibre loss (not collagen loss) — collagen primarily provides tensile strength while elastin provides elastic recoil. addressing sagging requires elastin restoration; conventional collagen-stimulating peptides cannot address the elastic fibre mechanism underlying ptosis.

Last Verified: Cosing database,elastin peptide technical data

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Stimulates collagen synthesis and wound healing while reducing inflammation – the primary active in centella asiatica's skin repair activity.

Why It's Used: Standardized centella active for precise wound healing, collagen stimulation, and anti-inflammatory dosing with superior consistency vs whole centella extract.

How It Works: Activates tgf-beta1 receptor signaling to upregulate collagen i, iii, and iv synthesis in fibroblasts. inhibits nf-kb for anti-inflammatory activity. promotes keratinocyte migration and proliferation for re-epithelialization. also strengthens lamellar body structures.

Typically Found In: Post-procedure recovery,wound healing serums,anti-aging products,sensitive skin formulas

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Collagen stimulation,wound healing,anti-inflammatory

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%–2%

SOURCING & ETHICS

Vegan Status: Yes – from centella asiatica

Halal Status: Yes

Source Notes: Extracted from centella asiatica aerial parts. standardized to madecassoside content for consistent bioactivity.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Madecassoside is the most water-soluble and bioavailable of the four major centella triterpene glycosides. its tgf-beta1-mediated collagen stimulation distinguishes it from other soothing actives – providing not just anti-inflammatory relief but active tissue remodeling and collagen neosynthesis.

Last Verified: Cosing database,bylka et al. centella review,liu et al. madecassoside collagen study

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Activates trpm8 cold thermoreceptors for intense cooling sensation and analgesic activity.

Why It's Used: The most potent cosmetic cooling agent – direct trpm8 agonist providing cooling sensation without actual temperature reduction for refreshing and analgesic formulations.

How It Works: Potent trpm8 (menthol receptor/cold thermosensor) agonist – activation at room temperature mimics cold sensation without actual cooling. anti-pruritic via trpm8 activation competing with itch c-fiber signaling. antimicrobial via membrane disruption.

Typically Found In: Cooling products,scalp treatments,oral care,pain relief,foot care,after-sun

TECHNICAL DETAILS

Primary Category: Active ingredient – cooling sensory terpenoid

Secondary Functions: Redness reduction,anti-inflammatory,calming

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – from mentha piperita or synthetic

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate; potential sensitizer

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Avoid near eyes. use with caution at concentrations above 1% for sensitive skin.

SAFETY & COMPATIBILITY

Safety Profile: Eu max 4.5% (leave-on); regulations vary by application site. avoid on infants' face.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Menthol's exceptional cooling potency stems from its ec50 for trpm8 activation of approximately 10μm (vs camphor's ec50 of ~5mm – 500× lower potency). this 500× potency advantage explains why even tiny concentrations of menthol provide intense cooling, while much higher concentrations of camphor are required for equivalent sensation.

Last Verified: Cosing database,mckemy et al. menthol trpm8 discovery,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Activates trpm8 cold thermoreceptors for intense cooling sensation and analgesic activity.

Why It's Used: The most potent cosmetic cooling agent – direct trpm8 agonist providing cooling sensation without actual temperature reduction for refreshing and analgesic formulations.

How It Works: Potent trpm8 (menthol receptor/cold thermosensor) agonist – activation at room temperature mimics cold sensation without actual cooling. anti-pruritic via trpm8 activation competing with itch c-fiber signaling. antimicrobial via membrane disruption.

Typically Found In: Cooling products,scalp treatments,oral care,pain relief,foot care,after-sun

TECHNICAL DETAILS

Primary Category: Active ingredient – cooling sensory terpenoid

Secondary Functions: Redness reduction,anti-inflammatory,calming

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – from mentha piperita or synthetic

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate; potential sensitizer

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Avoid near eyes. use with caution at concentrations above 1% for sensitive skin.

SAFETY & COMPATIBILITY

Safety Profile: Eu max 4.5% (leave-on); regulations vary by application site. avoid on infants' face.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Menthol's exceptional cooling potency stems from its ec50 for trpm8 activation of approximately 10μm (vs camphor's ec50 of ~5mm – 500× lower potency). this 500× potency advantage explains why even tiny concentrations of menthol provide intense cooling, while much higher concentrations of camphor are required for equivalent sensation.

Last Verified: Cosing database,mckemy et al. menthol trpm8 discovery,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Supports anti-aging skin structure by stimulating collagen and elastin synthesis and modulating skin matrix metalloproteinase activity.

Why It's Used: Peptide sequences mimic endogenous skin communication molecules, triggering cellular responses that decline with age — restoring youthful skin structure.

How It Works: Specific amino acid sequences bind to cell surface receptors or penetrate to fibroblasts where they activate growth factor pathways, tgf-β signaling, or mmp-inhibiting mechanisms, stimulating ecm remodeling.

Typically Found In: Anti-aging serums,ampoules,eye creams,firming moisturizers

TECHNICAL DETAILS

Primary Category: Bioactive peptides

Secondary Functions: Anti-aging,skin-conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.001–2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetic or recombinant peptide; no animal-derived material.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 0

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Retinol,vitamin c,hyaluronic acid,niacinamide

Avoid Combining With: Proteolytic enzymes (papain, bromelain); extreme ph

SCIENTIFIC NOTE

Cosmetic peptides are typically 2–10 amino acids, short enough for transdermal penetration but specific enough for receptor binding. their bioactivity depends on sequence (primary structure), lipophilization (e.g., palmitoyl modification increases skin penetration 10-fold), and resistance to skin proteases — often achieved through d-amino acid substitution or terminal modifications.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; j pept sci peptide cosmetic reviews; j cosmet dermatol clinical studies

Primary Sources: 2025-01-15