Neutrogena
Stubborn Acne™ Spot Drying Lotion
Stubborn Acne™ Spot Drying Lotion
Neutrogena
stubborn-acne-spot-drying-lotion
Moisturize
9818406715685
Morning or Evening?
How often will you use this product?
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Highlights
WHAT IS IT?
Spot treatment with 10% sulfur
FEATURES
Fast-acting, reduces redness, shrinks pimples, clinically proven results in one day
BEST FOR
oily
CHECKS
Free of dyes, oils, parabens, phthalates, silicon, sulfate, fragrance
Who Is It For?
Individuals With Acne-prone SkinWhat Does It Help With?
Acne Treatment Pimple Reduction Redness Relief Post-acne MarksBudget
Affordable (under $30)How To Use
Which routine should it be used in?
Instructions:
Key Information
What Neutrogena Says
Product Description:
Clear up acne while reducing redness and discomfort with Neutrogena Stubborn Acne™ Spot Drying Lotion. Clinically proven to provide fast-acting results, pimples look visibly clearer in just one day. This fast-acting acne is packed with 10% sulfur, the maximum level of sulfur available over-the-counter, to penetrate pores to help eliminate stubborn acne.
About the Brand:
Ingredients Overview
Ingredients List
Sulfur-10%, Isopropyl-Alcohol, Water, Calamine, Niacinamide, Zinc-Oxide, Zea-Mays-Corn-Starch, Magnesium-Aluminum-Silicate, Salicylic-Acid, Titanium-Dioxide
Key Ingredients
Sulfur, Niacinamide, Zinc Oxide, Salicylic Acid
Ingredients Details
Calamine
Common Name(s): Calamine,cosmetic active,functional ingredient
CAS Number: N/a
DESCRIPTION
What It Does: Delivers characteristic cosmetic function at recommended use concentration.
Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.
How It Works: Works through the mechanism of its molecular class as documented in peer-reviewed cosmetic literature.
Typically Found In: Skin care formulations
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–10%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Calamine has an established safety profile within the cosmetic regulatory framework at standard use concentrations.
Last Verified: Cosing database,calamine technical literature
Primary Sources: 2026-03-12
Isopropyl Alcohol
Common Name(s): Isopropyl alcohol,isopropyl alcohol (ipa),solvent antimicrobial astringent
CAS Number: N/a
DESCRIPTION
What It Does: Isopropyl alcohol dissolves oil-soluble and water-soluble cosmetic actives, provides rapid antimicrobial activity at concentrations above 60–70% by denaturing microbial proteins, delivers a refreshing cooling sensation through evaporative cooling on skin, and temporarily enhances the penetration of topical actives by transiently disrupting the stratum corneum lipid bilayer organisation.
Why It's Used: Formulators choose isopropyl alcohol for its irreplaceable combination of solvent power, antimicrobial activity, and penetration-enhancing properties. no other cosmetic solvent simultaneously provides the cooling sensory experience of alcohol (from evaporative cooling at the skin surface), the immediate antimicrobial activity required for sanitisers (from protein denaturation above 60%), and the transient sc lipid disruption that improves active ingredient delivery (essential in actives-rich toners and essences). for denatured alcohol specifically, denaturing agents (typically 5% isopropanol or bitrex) prevent consumption without affecting cosmetic function.
How It Works: Isopropyl alcohol works through multiple mechanisms depending on concentration: (1) solvent action — alcohol's hydroxyl group provides hydrogen bonding with water while the short alkyl chain provides interaction with organic solutes, enabling dissolution of both hydrophilic and moderately lipophilic cosmetic actives in a single solvent; (2) antimicrobial — above 60% concentration, ethanol denatures microbial proteins by disrupting non-covalent bonds maintaining protein secondary and tertiary structure — the alcohol molecules intercalate between protein chains, disrupting the hydrophobic interactions and hydrogen bonds that maintain enzyme active site geometry. this non-specific protein denaturation is immediately bactericidal and virucidal with no resistance mechanism possible; (3) sc penetration enhancement — at lower concentrations (5–30%), ethanol transiently fluidises the sc lipid bilayer by intercalating between the ordered lipid lamellae, disrupting the crystal packing and increasing lipid bilayer fluidity. this transient fluidisation increases the diffusion coefficient of co-applied actives through the sc for up to 30 minutes post-application; (4) astringency — alcohol's protein precipitating action at the skin surface contracts superficial proteins, temporarily tightening pores and reducing oiliness.
Typically Found In: Toners,hand sanitisers,actives serums
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 5%–95%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Ethanol concentration-dependent antimicrobial efficacy: below 40% — minimal bactericidal effect (insufficient protein denaturation); 40–60% — bacteriostatic, not bactericidal; 60–70% — peak bactericidal efficacy against both enveloped and non-enveloped viruses and vegetative bacteria (optimal water content maintains protein hydration required for denaturation to proceed); 80–90% — remains effective but slightly reduced from decreased water activity; 95–100% — reduced efficacy (insufficient water for protein denaturation). the 70% 'sweet spot' for sanitisers reflects this concentration-efficacy peak, not a formulation convenience.
Last Verified: Cosing database,isopropyl alcohol ethanol solvent antimicrobial review
Primary Sources: 2026-03-12
Magnesium Aluminum Silicate
Common Name(s): Magnesium aluminum silicate,cosmetic active,functional ingredient
CAS Number: N/a
DESCRIPTION
What It Does: Delivers characteristic cosmetic function at recommended use concentration.
Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.
How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.
Typically Found In: Skin care formulations
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–10%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Magnesium aluminum silicate has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.
Last Verified: Cosing database,magnesium aluminum silicate technical literature
Primary Sources: 2026-03-12
Niacinamide
Common Name(s): Vitamin b3,nicotinamide,pyridine-3-carboxamide
CAS Number: 98-92-0
DESCRIPTION
What It Does: Niacinamide strengthens the skin barrier, reduces visible pore size, regulates sebum production, fades dark spots, and improves skin texture and tone.
Why It's Used: It is used because it addresses multiple skin concerns at once without irritation, making it suitable for all skin types. it is stable in formulations and pairs well with most other actives.
How It Works: Niacinamide inhibits the transfer of melanosomes (pigment packets) to skin cells, reducing hyperpigmentation. it also stimulates ceramide synthesis to strengthen the skin barrier and reduces inflammation by modulating cytokine activity.
Typically Found In: Serums,moisturizers,toners,cleansers,eye creams,sunscreens,primers
TECHNICAL DETAILS
Primary Category: Active ingredient – vitamin
Secondary Functions: Barrier repair,brightening,anti-inflammatory
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 2%–10% (typical: 5%; higher concentrations may cause flushing in some individuals)
SOURCING & ETHICS
Vegan Status: Yes – synthetically produced
Halal Status: Yes – synthetic origin
Source Notes: Commercially produced via synthesis from nicotinic acid or 3-cyanopyridine. no animal-derived sources used in cosmetic-grade niacinamide.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low; concentrations above 10% may cause temporary flushing in sensitive individuals
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: At concentrations >10%, some users experience niacin flush (transient redness/tingling). generally very well-tolerated.
Safe for Sensitive Skin: Yes – one of the best-tolerated actives for sensitive skin
SAFETY & COMPATIBILITY
Safety Profile: Extensively studied and considered very safe. ewg hazard score: 1. no significant systemic toxicity concerns at topical concentrations.
Works Well With: Retinol,peptides,ahas/bhas,hyaluronic acid,ceramides,zinc,vitamin c,spf
Avoid Combining With: High concentrations of vitamin c (ascorbic acid) may theoretically convert to niacin – use at different times if using pure l-ascorbic acid above 15%
SCIENTIFIC NOTE
Niacinamide is a precursor to nad+ and nadp+, coenzymes vital to cellular energy metabolism. its benefits for dna repair and mitochondrial function make it a key ingredient in anti-aging strategies.
Last Verified: Cosing database,cir safety assessment,ewg skin deep,pubmed clinical studies
Primary Sources: 2026-03-12